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. 2017 May 10;4(1):13-21.
doi: 10.14744/nci.2017.85520. eCollection 2017.

Is duodenal biopsy appropriate in areas endemic for Helicobacter pylori?

Abdurrahman Sahin  1 , Gulcin Cihangiroglu  2 , Yilmaz Bilgic  1 , Turan Calhan  3 , Mustafa Cengiz  4
Affiliations

Is duodenal biopsy appropriate in areas endemic for Helicobacter pylori?

Abdurrahman Sahin et al. North Clin Istanb. .

Abstract

Objective: The primary reason for obtaining duodenal biopsy sample is to diagnose celiac disease. Helicobacter pylori (H. pylori) and drug injury are common causes of duodenitis. The aim of this retrospective study was to explore effects of H. pylori and drugs on duodenal mucosa.

Methods: Duodenal biopsy samples of patients who underwent upper gastrointestinal endoscopy (UGIE) between February 2014 and December 2014 were retrospectively examined. Clinical symptoms, referral indications, endoscopic findings, H. pylori status, and drug history were recorded. Duodenal biopsy findings were compared based on presence of H. pylori and drug history.

Results: Of 2389 patients who underwent UGIE, 206 had duodenal biopsy. Eight patients (3.9%) were diagnosed with celiac disease. After excluding cases with celiac disease, 76 patients of remaining 198 patients (36.9%) had duodenal histopathological abnormality. H. pylori was found in 95 (47.9%) patients. Drug usage was less common (42%). Of patients who had histopathological duodenitis, 59% were H. pylori-infected. Rate of duodenitis was higher in H. pylori (+) group than in H. pylori (-) group (45% vs 27.1%; odds ratio, 2.4; 95% confidence interval, 1.3-4.4; p=0.005). There was no difference between groups regarding drug use in terms of histopathological duodenitis.

Conclusion: H. pylori is the major contributor to duodenitis in high prevalence regions. Serological testing may be more appropriate before performing duodenal biopsy in patients with suspected celiac disease.

Keywords: Acetylsalicylic acid; Helicobacter pylori; celiac disease; duodenitis; nonsteroidal anti-inflammatory drugs.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

FIGURE 1
FIGURE 1
Participation flowchart. Patients in final assessment were adjusted according to presence of Helicobacter pylori and drug usage.
See this image and copyright information in PMC

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