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Review
. 2017 Jul;5(4):10.1128/microbiolspec.funk-0050-2016.
doi: 10.1128/microbiolspec.FUNK-0050-2016.

Fungal Recognition and Host Defense Mechanisms

I M Dambuza  1 , S M Levitz  2 , M G Netea  3 , G D Brown  1
Affiliations
Review

Fungal Recognition and Host Defense Mechanisms

I M Dambuza et al. Microbiol Spectr. 2017 Jul.

Abstract

Fungi have emerged as premier opportunistic microbes of the 21st century, having a considerable impact on human morbidity and mortality. The huge increase in incidence of these diseases is largely due to the HIV pandemic and use of immunosuppressive therapies, underscoring the importance of the immune system in defense against fungi. This article will address how the mammalian immune system recognizes and mounts a defense against medically relevant fungal species.

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Figures

FIGURE 1
FIGURE 1
More than half a century of immunogical theories.
FIGURE 2
FIGURE 2
Signaling pathways involved in antifungal immunity.
FIGURE 3
FIGURE 3
PRRs and the fungal components they recognize. (Adapted with modifications from reference 12).
FIGURE 4
FIGURE 4
Schematic representation of the sequential inflammatory immune reaction involved in antifungal immune responses.
See this image and copyright information in PMC

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