(+) or (-)-1-(9-fluorenyl)ethyl chloroformate as chiral derivatizing agent: A review

Abstract

Over the last 30years, (±)-1-(9-fluorenyl)ethyl chloroformate ((±)-FLEC) was used as a chiral derivatizing agent in various analytical applications involving a wide range of endogenous, pharmaceutical and environmentally relevant molecules. This comprehensive review aims to present all the significant aspects related to the state of the art in FLEC labeling and subsequent chiral separation of the resulting diastereomers using LC, SFC and CE techniques.

Keywords: (+) or (−)-1-(9-fluorenyl)ethyl chloroformate; Chiral derivatizing agent; Chiral separations; Derivatization; Diastereomers.