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Review
. 2018 Jan;19(1):35-41.
doi: 10.1016/j.cllc.2017.06.010. Epub 2017 Jul 6.

Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC

Nele Van Der Steen  1 , Yves Mentens  2 , Marc Ramael  3 , Leticia G Leon  4 , Paul Germonpré  5 , Jose Ferri  6 , David R Gandara  7 , Elisa Giovannetti  8 , Godefridus J Peters  9 , Patrick Pauwels  10 , Christian Rolfo  11
Affiliations
Review

Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC

Nele Van Der Steen et al. Clin Lung Cancer. 2018 Jan.

Abstract

Several oncogenic drivers have been identified in non-small cell lung cancer. Targeted therapies for these aberrations have already been successfully developed and implemented in clinical practice. Owing to improved sensitivity in genetic testing, more and more tumors with multiple driver mutations are identified, resulting in dilemmas for treating physicians whether and which targeted therapy to use. In this case series, we provide an overview of patients with intrinsic double mutations in oncogenic drivers and their reported response to targeted therapies, with a focus on epidermal growth factor receptor, anaplastic lymphoma kinase, cMET, and Kirsten rat sarcoma viral oncogene. We also include an unpublished case report on a patient with an epidermal growth factor receptor L858R and cMET exon 14 skipping.

Keywords: ALK; EGFR; KRAS; Non–small cell lung cancer; cMET.

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