Review
doi: 10.1016/j.canlet.2017.07.020.
Epub 2017 Jul 27.
miRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential
Affiliations
- PMID: 28757417
- DOI: 10.1016/j.canlet.2017.07.020
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Review
miRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential
Cancer Lett.
.
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that regulate many human genes including those involved in normal B-cell development. When these miRNAs are aberrantly expressed in B-cells they play key pathogenetic roles in the development and maintenance of B-cell lymphomas and by association may serve as useful biomarkers. In this review, we provide an overview of the importance of miRNAs to B-cell lymphomagenesis, as well as considering their use as biomarkers, and their potential usefulness for the clinic.
Keywords: B-cell lymphoma; Biomarker; Hodgkin lymphoma; Lymphoma; MicroRNA; Non-Hodgkin lymphoma.
Copyright © 2017 Elsevier B.V. All rights reserved.
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