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Comment
. 2017 Sep;14(9):730-732.
doi: 10.1038/cmi.2017.63. Epub 2017 Jul 31.

Message in a bottle from the tumor microenvironment: tumor-educated DCs instruct B cells to participate in immunosuppression

Francesca Mion  1 , Silvia Tonon  1 , Viviana Valeri  1 , Carlo E Pucillo  1
Affiliations
Comment

Message in a bottle from the tumor microenvironment: tumor-educated DCs instruct B cells to participate in immunosuppression

Francesca Mion et al. Cell Mol Immunol. 2017 Sep.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The phenotype and effector weapon of Bregs vary depending on the specific tumor setting. Reported in the figure are some examples of the Breg subsets described in the contexts of murine and human cancers. Roles for the two most popular phenotype subsets of B cells that exert immunosuppressive functions in the murine system, CD19+CD1dhighCD5+ cells and transitional 2 marginal-zone precursor (T2-MZP) cells, have been shown in models of pancreatic cancer and melanoma, respectively. Regulatory B cells with a plasma cell-like phenotype play a role in autochthonous transgenic adenocarcinoma in a mouse prostate (TRAMP) model of metastatic prostate cancer and human renal cell carcinoma. In humans, an upregulation of IL-10-producing B cells was associated with tumor progression in non-small cell lung carcinoma patients.
Figure 2
Figure 2
Schematic recapitulation of TDC-mediated generation of FcγRIIlow/− IL-10-producing B cells in HCC. In this issue of Nature Communications, Ouyang et al. describe the mechanism leading to the expansion of a B-cell population with regulatory potential in hepatocellular carcinoma (HCC). Under the effect of soluble tumor-derived factors and in particular hyaluronan (HA) fragments, human monocytes differentiate into tolerogenic semimature DCs (TDCs), which are responsible for the generation of FcγRIIlow/−-activated B cells. CD95-CD95L interactions play a major role in this activation process. By producing IL-10, FcγRIIlow/−-activated B cells suppressed cytotoxic T-cell immunity and may therefore favor tumor progression.
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