Genetic susceptibility and periodontal disease: a retrospective study on a large italian sample

Abstract

Background: Periodontal disease (PD) is a multifactorial illness in which environment and host interact. The genetic component plays a key role in the onset of PD. In fact the genetic compound can modulate the inflammation of the mucous membranes and the loss of alveolar bone. The genetics of PD is not well understood. Previous studies suggest a strong association between PD occurrence and individual genetic profile. The role of genetic susceptibility could impact on the clinical manifestations of PD, and consequently on prevention and therapy.

Materials and methods: Genetic polymorphisms of VRD, IL6 and IL10 were investigated in Italian adults affected by PD. 571 cases classified according the criteria of the American Academy of Periodontology were included. All patients were Italian coming from three areas according to italian institute of statistics (ISTAT) (www.istat.it/it/archivio/regioni). The sample comprised 379 patients from North (66%), 152 from Central (26%) and 40 of South (8%).

Results: No significant differences were found among allele distribution.

Conclusion: Chronic PD is a complex disease caused by a combination of genetic susceptibility, patients habits (oral hygiene, smoking, alcohol consumption) and oral pathogens. In our report no differences were detected among three Italian regions in allele distribution.

Keywords: genetic susceptibility; oral disease; periodontal disease; periodontitis; population.

Figure 1

T-test results comparing IL6 variant allele carriers between three Italian geographic areas (Centre, North, South Italy).

Figure 2

T-test results comparing IL10 variant allele carriers between three Italian geographic areas (Centre, North, South Italy).

Figure 3

T-test results comparing VDR variant allele carriers between three Italian geographic areas (Centre, North, South Italy).