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. 2017 Apr 10;10(1):20-27.
doi: 10.11138/orl/2017.10.1.020. eCollection 2017 Jan-Mar.

Genetic susceptibility and periodontal disease: a retrospective study on a large italian sample

L Tettamanti  1 , R M Gaudio  2 , A Iapichino  3 , D Mucchi  4 , A Tagliabue  1
Affiliations

Genetic susceptibility and periodontal disease: a retrospective study on a large italian sample

L Tettamanti et al. Oral Implantol (Rome). .

Abstract

Background: Periodontal disease (PD) is a multifactorial illness in which environment and host interact. The genetic component plays a key role in the onset of PD. In fact the genetic compound can modulate the inflammation of the mucous membranes and the loss of alveolar bone. The genetics of PD is not well understood. Previous studies suggest a strong association between PD occurrence and individual genetic profile. The role of genetic susceptibility could impact on the clinical manifestations of PD, and consequently on prevention and therapy.

Materials and methods: Genetic polymorphisms of VRD, IL6 and IL10 were investigated in Italian adults affected by PD. 571 cases classified according the criteria of the American Academy of Periodontology were included. All patients were Italian coming from three areas according to italian institute of statistics (ISTAT) (www.istat.it/it/archivio/regioni). The sample comprised 379 patients from North (66%), 152 from Central (26%) and 40 of South (8%).

Results: No significant differences were found among allele distribution.

Conclusion: Chronic PD is a complex disease caused by a combination of genetic susceptibility, patients habits (oral hygiene, smoking, alcohol consumption) and oral pathogens. In our report no differences were detected among three Italian regions in allele distribution.

Keywords: genetic susceptibility; oral disease; periodontal disease; periodontitis; population.

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Figures

Figure 1
Figure 1
T-test results comparing IL6 variant allele carriers between three Italian geographic areas (Centre, North, South Italy).
Figure 2
Figure 2
T-test results comparing IL10 variant allele carriers between three Italian geographic areas (Centre, North, South Italy).
Figure 3
Figure 3
T-test results comparing VDR variant allele carriers between three Italian geographic areas (Centre, North, South Italy).
See this image and copyright information in PMC

References

    1. Lauritano D, Martinelli M, Mucchi D, Palmieri A, Muzio LL, Carinci F. Bacterial load of periodontal pathogens among Italian patients with chronic periodontitis: A comparative study of three different areas. Journal of Biological Regulators and Homeostatic Agents. 2016;30(2):149–54. - PubMed
    1. Lauritano D, Scapoli L, Mucchi D, Cura F, Muzio LLO, Carinci F. Infectogenomics: Lack of association between vdr, il6, il10 polymorphisms and “red Complex” bacterial load in a group of Italian adults with chronic periodontal disease. Journal of Biological Regulators and Homeostatic Agents. 2016;30(2):155–60. - PubMed
    1. Checchi L, Gatto MR, Checchi V, Carinci F. Bacteria prevalence in a large Italian population sample: A clinical and microbiological study. Journal of Biological Regulators and Homeostatic Agents. 2016;30(2):199–208. - PubMed
    1. Meynardi F, Pasqualini ME, Rossi F, Dal Carlo L, Biancotti P, Carinci F. Correlation between dysfunctional occlusion and periodontal bacterial profile. J Biol Regul Homeost Agents. 2016;30(2 Suppl 1):115–21. - PubMed
    1. Lombardo L, Carinci F, Martini M, Gemmati D, Nardone M, Siciliani G. Quantitive evaluation of dentin sialoprotein (DSP) using microbeads - A potential early marker of root resorption. ORAL and Implantology. 2016;9(3):132–42. - PMC - PubMed

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