Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr;6(2):239.
doi: 10.4172/2167-7921.1000239. Epub 2017 Apr 28.

Role of MicroRNA in Osteoarthritis

Mingcai Zhang  1 , Kate Lygrisse  1 , Jinxi Wang  1   2
Affiliations

Role of MicroRNA in Osteoarthritis

Mingcai Zhang et al. J Arthritis. 2017 Apr.

Abstract

Although the potential effect of aberrant expression of catabolic and anabolic genes on the development of osteoarthritis (OA) is well-documented, the regulatory mechanism for the expression of these genes in articular chondrocytes remains to be elucidated. The recent advances in epigenetic studies have identified microRNA (miRNA) as one of the epigenetic mechanisms for the regulation of gene expression. This mini review highlights the role of miRNA in the regulation of gene expression in articular chondrocytes and its significance in the pathogenesis of OA, with a discussion on the potential of miRNA as a new biomarker and therapeutic target for OA. Further investigations are required to determine the specificity, sensitivity, and efficacy of miRNA for clinical applications.

Keywords: Biomarker; Epigenetics; Gene expression; MicroRNA; Osteoarthritis.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Saetrom P, Snove O, Jr, Rossi JJ. Epigenetics and microRNAs. Pediatr Res. 2007;61:17r–23r. - PubMed
    1. Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150:12–27. - PubMed
    1. Murphy L, Helmick CG. The impact of osteoarthritis in the United States: a population-health perspective. Am J Nurs. 2012;112:S13–S19. - PubMed
    1. Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet. 2006;15(Spec No 1):R17–R29. - PubMed
    1. Ha M, Kim VN. Regulation of microRNA biogenesis. Nature reviews Molecular cell biology. 2014;8:509–524. - PubMed

LinkOut - more resources