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. 2017 Apr;6(2):239.
doi: 10.4172/2167-7921.1000239. Epub 2017 Apr 28.

Role of MicroRNA in Osteoarthritis

Mingcai Zhang  1 , Kate Lygrisse  1 , Jinxi Wang  1   2
Affiliations

Role of MicroRNA in Osteoarthritis

Mingcai Zhang et al. J Arthritis. 2017 Apr.

Abstract

Although the potential effect of aberrant expression of catabolic and anabolic genes on the development of osteoarthritis (OA) is well-documented, the regulatory mechanism for the expression of these genes in articular chondrocytes remains to be elucidated. The recent advances in epigenetic studies have identified microRNA (miRNA) as one of the epigenetic mechanisms for the regulation of gene expression. This mini review highlights the role of miRNA in the regulation of gene expression in articular chondrocytes and its significance in the pathogenesis of OA, with a discussion on the potential of miRNA as a new biomarker and therapeutic target for OA. Further investigations are required to determine the specificity, sensitivity, and efficacy of miRNA for clinical applications.

Keywords: Biomarker; Epigenetics; Gene expression; MicroRNA; Osteoarthritis.

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Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest

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