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. 2017:2017:9251358.
doi: 10.1155/2017/9251358. Epub 2017 Jul 3.

Antihyperglycemic and Antihyperlipidemic Activity of Hydroponic Stevia rebaudiana Aqueous Extract in Hyperglycemia Induced by Immobilization Stress in Rabbits

Anush Aghajanyan  1   2 , Zaruhi Movsisyan  1 , Armen Trchounian  1   2
Affiliations

Antihyperglycemic and Antihyperlipidemic Activity of Hydroponic Stevia rebaudiana Aqueous Extract in Hyperglycemia Induced by Immobilization Stress in Rabbits

Anush Aghajanyan et al. Biomed Res Int. 2017.

Abstract

Diabetes mellitus (DM) is a serious worldwide problem related to human hyperglycemia. Thus, herbal preparations with antihyperglycemic properties especially leaf extracts of hydroponic Stevia rebaudiana (SR) would be useful in hyperglycemia treatment. The antihyperglycemic potential of this medicinal plant grown using hydroponics methods has been evaluated. Significant reduction of some biochemical characteristics for sugars and fatty acids in blood, liver, and muscle especially fasting glucose levels, serum triglycerides, LDL-cholesterol, total cholesterol levels, and increased HDL-cholesterol ones was shown with SR aqueous extract treatment. Therefore, the aqueous extract of SR is suggested to have antihyperglycemic and antihyperlipidemic activity and to restore liver and muscle glycogen levels (hepatoprotective effects) in hyperglycemia induced by immobilization stress in rabbits and might be recommended for treatment of DM (hyperglycemia).

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Figures

Figure 1
Figure 1
The effects of SR aqueous extract on fasting blood glucose levels in nonhyperglycemic and hyperglycemic rabbits. All data are expressed as mean ± SEM for 3 animals per group. For details see Materials and Methods and the text. ∗Significantly different levels compared to the nonhyperglycemic group (p < 0.05). ∗∗Significantly different levels compared to the hyperglycemic control group (p < 0.05).
Figure 2
Figure 2
The effects of SR aqueous extracts on liver (a) and muscle (b) glycogen levels. All data are expressed as mean ± SEM for 3 animals per group. For details see Materials and Methods and the text.
Figure 3
Figure 3
The effects of SR aqueous extract on the body weight of rabbits.  ∗Significantly different levels compared to the nonhyperglycemic group (p < 0.01). ∗∗Significantly different levels compared to the hyperglycemic control group (p < 0.01).
See this image and copyright information in PMC

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