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Meta-Analysis
. 2018 Jan;46(1):3-10.
doi: 10.1177/0300060517717359. Epub 2017 Jul 31.

Efficacy of parecoxib sodium on postoperative shivering: meta-analysis of clinical trials

Yu Zhu  1 , Chengmao Zhou  2 , Yuting Yang  3 , Yijian Chen  4
Affiliations
Meta-Analysis

Efficacy of parecoxib sodium on postoperative shivering: meta-analysis of clinical trials

Yu Zhu et al. J Int Med Res. 2018 Jan.

Abstract

Objective To evaluate the effect of parecoxib on preventing postoperative shivering. Methods Main outcomes were the relative risk (odds ratio, OR) and 95% confidence interval (CI) relative to the incidence of shivering. Results Fourteen trials with 1,175 patients were analyzed. The pooled evidence suggested that parecoxib sodium, given before anesthesia or postoperatively (only 4 cases), had the potential to prevent postoperative shivering (OR = 0.21, 95% CI, 0.16, 0.29). Compared with the placebo, parecoxib sodium significantly lowered the incidence of postoperative shivering as follows: mild shivering [OR = 0.51, 95% CI (0.35, 0.74)]; moderate shivering [OR = 0.28, 95% CI (0.18, 0.45)]; severe shivering [OR = 0.18, 95% CI (0.10, 0.33)]. Compared with placebo, there was no significant association of parecoxib sodium with restlessness [OR = 0.95, 95% CI (0.59, 1.52)] or nausea/vomiting [OR = 0.24, 95% CI (0.09, 0.66)]. In addition, pethidine rescue was used significantly more often in the control group than in the parecoxib sodium group [OR = 0.22, 95% CI (0.09, 0.53)]. Conclusions Parecoxib sodium may be an effective strategy for preventing postoperative shivering.

Keywords: Parecoxib sodium; RCT; meta-analysis; pethidine rescue; postoperative; prevention; shivering.

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Figures

Figure 1.
Figure 1.
Flow chart.
Figure 2.
Figure 2.
Pooled evidence from 14 trials of post-anesthesia shivering: parecoxib sodium versus placebo.
See this image and copyright information in PMC

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