Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 31;12(7):e0181836.
doi: 10.1371/journal.pone.0181836. eCollection 2017.

HBV infection in untreated HIV-infected adults in Maputo, Mozambique

Lúcia Mabalane Chambal  1 , Eduardo Samo Gudo  2   3 , Awa Carimo  1 , Rita Corte Real  4 , Nédio Mabunda  2 , Cremildo Maueia  2 , Adolfo Vubil  2 , Ana Flora Zicai  2 , Nilesh Bhatt  2 , Francisco Antunes  5
Affiliations

HBV infection in untreated HIV-infected adults in Maputo, Mozambique

Lúcia Mabalane Chambal et al. PLoS One. .

Erratum in

Abstract

Background: HIV/ HBV coinfected patients are at high risk of developing chronic HBV infection, liver cirrhosis and hepatocellular carcinoma. In Mozambique, where HIV prevalence is one of the highest in the world, HIV-infected patients are scarcely characterized in terms of HBV coinfection and 3TC-resistance mutations profile.

Methods: To characterize ART-naïve HIV-infected adults, with and without HBV coinfection, a cross-sectional study was conducted between May and November 2012 in two health centers from Maputo city, Mozambique. Subjects were consecutively enrolled in the study and, then, tested for hepatitis B surface antigen (HBsAg). Moreover, CD4+ T cells count, HBV DNA in plasma, HBV genotyping and 3TC-resistance mutations profile of HBV were assessed in HIV/HBV coinfected patients.

Results: In total, 518 patients were enrolled in the study. The median age was 33 years old and 66.8% were women. The median CD4+ T cells count was 361 cells/mm3 and 47 (9.1%) were coinfected with HBV. Out of 46 coinfected patients, 24 (55.2%) had HBV DNA ≥ 20 - < 20 000 and 12 (26.1%) had HBV-DNA ≥20 000. APRI > 2.0 was reported in 4.3% of coinfected and 1.7% of monoinfected patients (p = 0.228), while FIB-4 > 3.25 was reported in 4.4% of coinfected and 1.3% of monoinfected patients (p = 0.112). Genotype A was the most frequent, identified in 25/27 (92.6%) patients, whereas genotype E was present in 2/27 (7.4%) patients. No patient had 3TC-resistance mutations.

Conclusions: This study showed that HBV coinfection was prevalent among ART-naïve HIV-infected adults in Mozambique. Overall, these data highlight the importance of screening HBV coinfection as an integrated measure of HIV routine care to improve health conditions and treatment of HIV/HBV coinfected patients.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of participant’s recruitment and testing.
The flow chart depicts the naïve HIV-infected patients enrolled in the study from two health centers in Maputo, between May and November 2012. Abbreviations: ARV–antiretroviral treatment; HBV VL–Hepatitis B viral load.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. UNAIDS. AIDSInfo 2015 2015. Available from: http://aidsinfo.unaids.org/.
    1. Hoffmann CJ, Thio CL. Clinical implications of HIV and hepatitis B co-infection in Asia and Africa. Lancet Infect Dis. 2007;7(6):402–9. doi: 10.1016/S1473-3099(07)70135-4 . - DOI - PubMed
    1. Puoti M, Torti C, Bruno R, Filice G, Carosi G. Natural history of chronic hepatitis B in co-infected patients. J Hepatol. 2006;44(1 Suppl):S65–70. doi: 10.1016/j.jhep.2005.11.015 . - DOI - PubMed
    1. Alter MJ. Epidemiology of viral hepatitis and HIV co-infection. J Hepatol. 2006;44(1 Suppl):S6–9. doi: 10.1016/j.jhep.2005.11.004 . - DOI - PubMed
    1. Easterbrook P, Sands A, Harmanci H. Challenges and priorities in the management of HIV/HBV and HIV/HCV coinfection in resource-limited settings. Semin Liver Dis. 2012;32(2):147–57. doi: 10.1055/s-0032-1316476 . - DOI - PubMed

MeSH terms