Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 31;12(7):e0181748.
doi: 10.1371/journal.pone.0181748. eCollection 2017.

THPdb: Database of FDA-approved peptide and protein therapeutics

Salman Sadullah Usmani  1 , Gursimran Bedi  1 , Jesse S Samuel  1 , Sandeep Singh  1 , Sourav Kalra  1 , Pawan Kumar  1 , Anjuman Arora Ahuja  1 , Meenu Sharma  1 , Ankur Gautam  1 , Gajendra P S Raghava  1
Affiliations

THPdb: Database of FDA-approved peptide and protein therapeutics

Salman Sadullah Usmani et al. PLoS One. .

Abstract

THPdb (http://crdd.osdd.net/raghava/thpdb/) is a manually curated repository of Food and Drug Administration (FDA) approved therapeutic peptides and proteins. The information in THPdb has been compiled from 985 research publications, 70 patents and other resources like DrugBank. The current version of the database holds a total of 852 entries, providing comprehensive information on 239 US-FDA approved therapeutic peptides and proteins and their 380 drug variants. The information on each peptide and protein includes their sequences, chemical properties, composition, disease area, mode of activity, physical appearance, category or pharmacological class, pharmacodynamics, route of administration, toxicity, target of activity, etc. In addition, we have annotated the structure of most of the protein and peptides. A number of user-friendly tools have been integrated to facilitate easy browsing and data analysis. To assist scientific community, a web interface and mobile App have also been developed.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic representation of THPdb architecture.
Fig 2
Fig 2. Overview of the function/mode of activity based classification of therapeutic proteins and peptides.
Fig 3
Fig 3. The flow diagram explains the work and design of THPdb mobile application.
Fig 4
Fig 4. A schematic representation of distribution of therapeutic peptides and proteins based on disease, function/ mode of activity, route of administration, and pharmacological class.
Fig 5
Fig 5. Representative screen shots of THPdb demonstrating the flow of information after submission of a query in simple search page.
See this image and copyright information in PMC

References

    1. Antosova Z, Mackova M, Kral V, Macek T. Therapeutic application of peptides and proteins: parenteral forever? Trends Biotechnol. 2009;27(11):628–35. Epub 2009/09/22. doi: 10.1016/j.tibtech.2009.07.009 . - DOI - PubMed
    1. Singh S, Singh H, Tuknait A, Chaudhary K, Singh B, Kumaran S, et al. PEPstrMOD: structure prediction of peptides containing natural, non-natural and modified residues. Biol Direct. 2015;10:73 Epub 2015/12/23. doi: 10.1186/s13062-015-0103-4 ; PubMed Central PMCID: PMCPMC4687368. - DOI - PMC - PubMed
    1. Craik DJ, Fairlie DP, Liras S, Price D. The future of peptide-based drugs. Chem Biol Drug Des. 2013;81(1):136–47. Epub 2012/12/21. doi: 10.1111/cbdd.12055 . - DOI - PubMed
    1. Bruno BJ, Miller GD, Lim CS. Basics and recent advances in peptide and protein drug delivery. Ther Deliv. 2013;4(11):1443–67. Epub 2013/11/16. doi: 10.4155/tde.13.104 ; PubMed Central PMCID: PMCPMC3956587. - DOI - PMC - PubMed
    1. Fosgerau K, Hoffmann T. Peptide therapeutics: current status and future directions. Drug Discov Today. 2015;20(1):122–8. Epub 2014/12/03. doi: 10.1016/j.drudis.2014.10.003 . - DOI - PubMed