Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions

Mohan K Raizada¹, Bina Joe², Nathan S Bryan², Eugene B Chang², Floyd E Dewhirst², Gary G Borisy², Zorina S Galis², Wendy Henderson², Pedro A Jose², Christian J Ketchum², Johanna W Lampe², Carl J Pepine², Jennifer L Pluznick², Dominic Raj², Douglas R Seals², Rachel A Gioscia-Ryan², W H Wilson Tang², Young S Oh¹

Affiliations

¹ From the Department of Physiology and Functional Genomics, College of Medicine (M.K.R.) and Division of Cardiovascular Medicine, Department of Medicine (C.J.P.), University of Florida, Gainesville; Department of Physiology and Pharmacology, University of Toledo, OH (B.J.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (N.S.B.); Department of Medicine, The University of Chicago, IL (E.B.C.); Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Cambridge, MA (F.E.D., G.G.B.); Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute (Z.S.G., Y.S.O.), Biobehavioral Unit, National Institute of Nursing Research (W.H.), and Division of Kidney, Urology and Hematology, National Institute of Diabetes and Digestive and Kidney Diseases(C.J.K.), National Institutes of Health, Bethesda, MD; Division of Renal Diseases and Hypertension, George Washington University School of Medicine, DC (P.A.J., D.R.); Public Health Division, Fred Hutchinson Cancer Research Center, Seattle, WA (J.W.L.); Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD (J.L.P.); Department of Integrative Physiology, University of Colorado (D.R.S., R.A.G.-R.); and Center for Clinical Genomics, Cleveland Clinic, OH (W.H.W.T.). mraizada@ufl.edu yoh@nhlbi.nih.gov.
² From the Department of Physiology and Functional Genomics, College of Medicine (M.K.R.) and Division of Cardiovascular Medicine, Department of Medicine (C.J.P.), University of Florida, Gainesville; Department of Physiology and Pharmacology, University of Toledo, OH (B.J.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (N.S.B.); Department of Medicine, The University of Chicago, IL (E.B.C.); Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Cambridge, MA (F.E.D., G.G.B.); Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute (Z.S.G., Y.S.O.), Biobehavioral Unit, National Institute of Nursing Research (W.H.), and Division of Kidney, Urology and Hematology, National Institute of Diabetes and Digestive and Kidney Diseases(C.J.K.), National Institutes of Health, Bethesda, MD; Division of Renal Diseases and Hypertension, George Washington University School of Medicine, DC (P.A.J., D.R.); Public Health Division, Fred Hutchinson Cancer Research Center, Seattle, WA (J.W.L.); Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD (J.L.P.); Department of Integrative Physiology, University of Colorado (D.R.S., R.A.G.-R.); and Center for Clinical Genomics, Cleveland Clinic, OH (W.H.W.T.).

PMID: 28760940
PMCID: PMC5792379
DOI: 10.1161/HYPERTENSIONAHA.117.09699

Review

Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions

Mohan K Raizada et al. Hypertension. 2017.

. 2017 Jul 31:HYPERTENSIONAHA.117.09699.

doi: 10.1161/HYPERTENSIONAHA.117.09699. Online ahead of print.

Authors

Affiliations

¹ From the Department of Physiology and Functional Genomics, College of Medicine (M.K.R.) and Division of Cardiovascular Medicine, Department of Medicine (C.J.P.), University of Florida, Gainesville; Department of Physiology and Pharmacology, University of Toledo, OH (B.J.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (N.S.B.); Department of Medicine, The University of Chicago, IL (E.B.C.); Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Cambridge, MA (F.E.D., G.G.B.); Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute (Z.S.G., Y.S.O.), Biobehavioral Unit, National Institute of Nursing Research (W.H.), and Division of Kidney, Urology and Hematology, National Institute of Diabetes and Digestive and Kidney Diseases(C.J.K.), National Institutes of Health, Bethesda, MD; Division of Renal Diseases and Hypertension, George Washington University School of Medicine, DC (P.A.J., D.R.); Public Health Division, Fred Hutchinson Cancer Research Center, Seattle, WA (J.W.L.); Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD (J.L.P.); Department of Integrative Physiology, University of Colorado (D.R.S., R.A.G.-R.); and Center for Clinical Genomics, Cleveland Clinic, OH (W.H.W.T.). mraizada@ufl.edu yoh@nhlbi.nih.gov.
² From the Department of Physiology and Functional Genomics, College of Medicine (M.K.R.) and Division of Cardiovascular Medicine, Department of Medicine (C.J.P.), University of Florida, Gainesville; Department of Physiology and Pharmacology, University of Toledo, OH (B.J.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (N.S.B.); Department of Medicine, The University of Chicago, IL (E.B.C.); Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Cambridge, MA (F.E.D., G.G.B.); Vascular Biology and Hypertension Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute (Z.S.G., Y.S.O.), Biobehavioral Unit, National Institute of Nursing Research (W.H.), and Division of Kidney, Urology and Hematology, National Institute of Diabetes and Digestive and Kidney Diseases(C.J.K.), National Institutes of Health, Bethesda, MD; Division of Renal Diseases and Hypertension, George Washington University School of Medicine, DC (P.A.J., D.R.); Public Health Division, Fred Hutchinson Cancer Research Center, Seattle, WA (J.W.L.); Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD (J.L.P.); Department of Integrative Physiology, University of Colorado (D.R.S., R.A.G.-R.); and Center for Clinical Genomics, Cleveland Clinic, OH (W.H.W.T.).

PMID: 28760940
PMCID: PMC5792379
DOI: 10.1161/HYPERTENSIONAHA.117.09699

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Figures

**FIGURE 1**
The Revised Mosaic Theory of Hypertension showing potential influences of microbiota in BP control and hypertension.

See this image and copyright information in PMC

References

1. Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation. 2017;135:e146–e603. - PMC - PubMed
1. Forouzanfar MH, Liu P, Roth GA, et al. Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990–2015. JAMA. 2017;317:165–182. - PubMed
1. Group SR, Wright JT, Jr, Williamson JD, et al. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015;373:2103–2116. - PMC - PubMed
1. Mahfoud F, Bakris G, Bhatt DL, Esler M, Ewen S, Fahy M, Kandzari D, Kario K, Mancia G, Weber M, Bohm M. Reduced blood pressure-lowering effect of catheter-based renal denervation in patients with isolated systolic hypertension: data from SYMPLICITY HTN-3 and the Global SYMPLICITY Registry. Eur Heart J. 2017;38:93–100. - PMC - PubMed
1. Rosa J, Widimsky P, Waldauf P, et al. Renal denervation in comparison with intensified pharmacotherapy in true resistant hypertension: 2-year outcomes of randomized PRAGUE-15 study. J Hypertens. 2017;35:1093–1099. - PubMed

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Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions

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Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions

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