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Case Reports
. 2017 Jul-Aug;27(4):321-323.
doi: 10.4103/0971-4065.202837.

Dengue Fever-induced Thrombotic Microangiopathy: An Unusual Cause of Renal Failure

V Bhargava  1 , P Gupta  1 , R Kauntia  1 , G Bajpai  1
Affiliations
Case Reports

Dengue Fever-induced Thrombotic Microangiopathy: An Unusual Cause of Renal Failure

V Bhargava et al. Indian J Nephrol. 2017 Jul-Aug.

Abstract

Dengue fever is a tropical infection, which is mosquito-borne disease, caused by dengue virus and spread by Aedes mosquitoes. The incidence of dengue fever has risen rapidly over the past few years. About half of dengue infections are asymptomatic, and a great majority present with fever and body ache. However, the occurrence of complications is well known, including acute kidney injury (AKI). AKI in dengue is usually attributable to a pre-renal cause. Thrombotic microangiopathy is an extremely rare complication of dengue fever, with only a few published case reports in medical literature. This case intends to highlight the importance of recognizing dengue fever-induced thrombotic microangiopathy by physicians and pathologists, enabling better diagnosis and management of this life-threatening condition.

Keywords: Acute kidney injury; dengue; renal failure; thrombotic microangiopathy.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Section showing glomerulus with microthrombi in glomeruli at hilar pole along with fibrillary appearance of mesangium. (H and E, ×200)
See this image and copyright information in PMC

References

    1. Gupta N, Srivastava S, Jain A, Chaturvedi UC. Dengue in India. Indian J Med Res. 2012;136:373–90. - PMC - PubMed
    1. Upadhaya BK, Sharma A, Khaira A, Dinda AK, Agarwal SK, Tiwari SC. Transient IgA nephropathy with acute kidney injury in a patient with dengue fever. Saudi J Kidney Dis Transpl. 2010;21:521–5. - PubMed
    1. Motla M, Manaktala S, Gupta V, Aggarwal M, Bhoi SK, Aggarwal P, et al. Sonographic evidence of ascites, pleura-pericardial effusion and gallbladder wall edema for dengue fever. Prehosp Disaster Med. 2011;26:335–41. - PubMed
    1. Noris M, Mescia F, Remuzzi G. STEC-HUS, atypical HUS and TTP are all diseases of complement activation. Nat Rev Nephrol. 2012;8:622–33. - PubMed
    1. Mehra N, Patel A, Abraham G, Reddy YN, Reddy YN. Acute kidney injury in dengue fever using Acute Kidney Injury Network criteria: Incidence and risk factors. Trop Doct. 2012;42:160–2. - PubMed

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