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. 2017 Jun;12(6):938-944.
doi: 10.4103/1673-5374.208576.

High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced afterdischarges

Zhi-Wei Ren  1 , Yong-Jie Li  1 , Tao Yu  1 , Duan-Yu Ni  1 , Guo-Jun Zhang  1 , Wei Du  1 , Yuan-Yuan Piao  1 , Xiao-Xia Zhou  1
Affiliations

High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced afterdischarges

Zhi-Wei Ren et al. Neural Regen Res. 2017 Jun.

Abstract

Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion, (1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area. (2) A higher brief-pulse stimulation frequency (especially 100 Hz) was more likely to terminate an afterdischarge. (3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.

Keywords: afterdischarges; cortical electrical stimulation; functional brain mapping; high frequency stimulation; intractable epilepsy; low frequency stimulation; nerve regeneration; neural regeneration; neuromodulation.

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Conflict of interest statement

Conflicts of interest: None declared.

Figures

Figure 1
Figure 1
Flow chart of the study.
Figure 2
Figure 2
Schematic diagram of the effect of brief-pulse stimulation on cortical electrical stimulation-induced afterdischarge.
Figure 3
Figure 3
Different afterdischarge types with different frequencies of brief-pulse stimulation (BPS).
Figure 4
Figure 4
Effect of BPS on AD extension and BPS intensity. (A) Box plot of AD extension (number of electrodes displaying AD waveforms) for the BPS effective group and ineffective group (P = 0.019, one-way analysis of variance), indicating the smaller the AD, the easier the AD to terminate. Thus, BPS was more effective when the AD did not extend into the surrounding brain area. (B) Box plot of BPS intensity for the BPS effective and ineffective groups (P = 0.021, one-way analysis of variance), indicating that the BPS intensity in the BPS effective group was lower than that in the BPS ineffective group. AD: Afterdischarge; BPS: brief-pulse stimulation.
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