Management of metastatic colorectal cancer patients: guidelines of the Italian Medical Oncology Association (AIOM)

Abstract

In the past 15 years, the outcome for patients with metastatic colorectal cancer has substantially improved owing to the availability of new cytotoxic and biological agents along with many significant advances in molecular selection, the use of personalised therapy and locoregional treatment, a more widespread sharing of specific professional experiences (multidisciplinary teams with oncologists, surgeons, radiotherapists, radiologists, biologists and pathologists), and the adoption of patient-centred healthcare strategies. The Italian Medical Oncology Association (AIOM) has developed evidence-based recommendations to help oncologists and all professionals involved in the management of patients with metastatic colorectal cancer in their daily clinical practice.

Keywords: AIOM; Italian; Metastatic colorectal cancer; guidelines; recommendation.

Figure 1

Algorithms for the management of metastatic colorectal cancer: (A) resectable metastatic disease; (B) metastatic disease, first-line; (C) metastatic disease, subsequent lines. 5-FU, 5-fluorouracil; Aflib, aflibercept; Bev, bevacizumab; Cape, capecitabine; Cet, cetuximab; CT, chemotherapy; EGFR, epidermal growth factor receptor; FOLFIRI, 5-fluorouracil+lederfolin+irinotecan; FOLFIRI, folinic acid, 5-FU and irinotecan; FOLFOX, folinic acid, 5-FU and oxaliplatin; LV, lederfolin; mut, mutant; PD, progressive disease; PS, performace status; pts, patients; RT, radiotherapy; wt, wild type; XELOX, capecitabine+oxaliplatin.