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Review
. 2017:2017:3635609.
doi: 10.1155/2017/3635609. Epub 2017 Jul 6.

Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence

Suneel Kumar Garg  1 , Omender Singh  1 , Deven Juneja  1 , Niraj Tyagi  2 , Amandeep Singh Khurana  3 , Amit Qamra  3 , Salman Motlekar  3 , Hanmant Barkate  3
Affiliations
Review

Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence

Suneel Kumar Garg et al. Crit Care Res Pract. 2017.

Abstract

Polymyxin B has resurged in recent years as a last resort therapy for Gram-negative multidrug-resistant (MDR) and extremely drug resistant (XDR) infections. Understanding newer evidence on polymyxin B is necessary to guide clinical decision making. Here, we present a literature review of polymyxin B in Gram-negative infections with update on its pharmacology.

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Figures

Figure 1
Figure 1
Structure of polymyxin B.
Figure 2
Figure 2
Bactericidal activity of all monotherapy and polymyxin B combination treatments in XDR A. baumannii [44].
Figure 3
Figure 3
Comparison of polymyxin B combination treatments in different outcomes [45]. PB: polymyxin B, CP: carbapenem, R: Rifampin, Ampi/Sul: Ampicillin/Sulbactam, and T: Tigecycline.
See this image and copyright information in PMC

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