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. 2017 Dec;53(6):883-897.
doi: 10.1007/s11262-017-1501-8. Epub 2017 Jul 31.

Two novel poxviruses with unusual genome rearrangements: NY_014 and Murmansk

Chad Smithson  1 , Hermann Meyer  2 , Crystal M Gigante  3 , Jinxin Gao  3 , Hui Zhao  3 , Dhwani Batra  3 , Inger Damon  3 , Chris Upton  4 , Yu Li  5
Affiliations

Two novel poxviruses with unusual genome rearrangements: NY_014 and Murmansk

Chad Smithson et al. Virus Genes. 2017 Dec.

Abstract

The genome sequence and annotation of two novel poxviruses, NY_014 and Murmansk, are presented. Despite being isolated on different continents and from different hosts, the viruses are relatively similar, albeit distinct species. The closest known relative of the novel viruses is Yoka poxvirus. Five novel genes were found in these genomes, two of which were MHC class I homologs. Although the core of these genomes was well conserved, the terminal regions showed significant variability with large deletions and surprising evidence of recombination with orthopoxviruses.

Keywords: Complete genome; Murmansk; Orthopoxvirus; Poxvirus; Virus virulence; Yoka poxvirus; Zoonotic.

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