Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease

doi:10.1007/s12264-017-0160-z

Review

. 2017 Oct;33(5):543-551.

doi: 10.1007/s12264-017-0160-z. Epub 2017 Jul 31.

Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease

Ying Wang^{1

2}, Zhaofei Yang^{1

2}, Weidong Le^{3

4

5}

Affiliations

¹ Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China.
² Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China.
³ Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China. wdle@sibs.ac.cn.
⁴ Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China. wdle@sibs.ac.cn.
⁵ Collaborative Innovation Center for Brain Science, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China. wdle@sibs.ac.cn.

PMID: 28762215
PMCID: PMC5636733
DOI: 10.1007/s12264-017-0160-z

Review

Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease

Ying Wang et al. Neurosci Bull. 2017 Oct.

. 2017 Oct;33(5):543-551.

doi: 10.1007/s12264-017-0160-z. Epub 2017 Jul 31.

Authors

Ying Wang^{1

2}, Zhaofei Yang^{1

2}, Weidong Le^{3

4

5}

Affiliations

¹ Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China.
² Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China.
³ Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China. wdle@sibs.ac.cn.
⁴ Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China. wdle@sibs.ac.cn.
⁵ Collaborative Innovation Center for Brain Science, the First Affiliated Hospital, Dalian Medical University, Dalian, 116021, China. wdle@sibs.ac.cn.

PMID: 28762215
PMCID: PMC5636733
DOI: 10.1007/s12264-017-0160-z

Abstract

Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder after Alzheimer's disease. To date, the clinical diagnosis of PD is primarily based on the late onset of motor impairments. Unfortunately, at this stage, most of the dopaminergic neurons may have already been lost, leading to the limited clinical benefits of current therapeutics. Therefore, early identification of PD, especially at the prodromal stage, is still a main challenge in the diagnosis and management of this disease. Recently, microRNAs (miRNAs) in cerebrospinal fluid or peripheral blood have been proposed as putative biomarkers to assist in PD diagnosis and therapy. In this review, we systematically summarize the changes of miRNA expression profiles in PD patients, and highlight their putative roles in the diagnosis and treatment of this devastating disease.

Keywords: Biomarker; Diagnosis; MicroRNA; Parkinson’s disease.

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Figures

**Fig. 1**
Bioinformatics and experiments are used to screen for miRNA target genes. GO gene ontology, *KEGG* kyoto encyclopedia of genes and genomes.

See this image and copyright information in PMC

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References

1. Grasso M, Piscopo P, Crestini A, Confaloni A, Denti MA. Circulating microRNAs in neurodegenerative diseases. EXS. 2015;106:151–169. - PubMed
1. Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson’s disease. Nat Genet. 2010;42:781–785. doi: 10.1038/ng.642. - DOI - PMC - PubMed
1. De Rosa P, Marini ES, Gelmetti V, Valente EM. Candidate genes for Parkinson disease: Lessons from pathogenesis. Clin Chim Acta. 2015;449:68–76. doi: 10.1016/j.cca.2015.04.042. - DOI - PubMed
1. Klein C, Westenberger A. Genetics of Parkinson’s disease. Cold Spring Harb Perspect Med. 2012;2:a008888. doi: 10.1101/cshperspect.a008888. - DOI - PMC - PubMed
1. Saghazadeh A, Rezaei N. MicroRNA machinery in Parkinson’s disease: a platform for neurodegenerative diseases. Expert Rev Neurother. 2015;17:1–27. doi: 10.1586/14737175.2015.1114886. - DOI - PubMed

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[1] Grasso M, Piscopo P, Crestini A, Confaloni A, Denti MA. Circulating microRNAs in neurodegenerative diseases. EXS. 2015;106:151–169. - PubMed

[2] Grasso M, Piscopo P, Crestini A, Confaloni A, Denti MA. Circulating microRNAs in neurodegenerative diseases. EXS. 2015;106:151–169. - PubMed

[3] Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson’s disease. Nat Genet. 2010;42:781–785. doi: 10.1038/ng.642. - DOI - PMC - PubMed

[4] Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson’s disease. Nat Genet. 2010;42:781–785. doi: 10.1038/ng.642. - DOI - PMC - PubMed

[5] De Rosa P, Marini ES, Gelmetti V, Valente EM. Candidate genes for Parkinson disease: Lessons from pathogenesis. Clin Chim Acta. 2015;449:68–76. doi: 10.1016/j.cca.2015.04.042. - DOI - PubMed

[6] De Rosa P, Marini ES, Gelmetti V, Valente EM. Candidate genes for Parkinson disease: Lessons from pathogenesis. Clin Chim Acta. 2015;449:68–76. doi: 10.1016/j.cca.2015.04.042. - DOI - PubMed

[7] Klein C, Westenberger A. Genetics of Parkinson’s disease. Cold Spring Harb Perspect Med. 2012;2:a008888. doi: 10.1101/cshperspect.a008888. - DOI - PMC - PubMed

[8] Klein C, Westenberger A. Genetics of Parkinson’s disease. Cold Spring Harb Perspect Med. 2012;2:a008888. doi: 10.1101/cshperspect.a008888. - DOI - PMC - PubMed

[9] Saghazadeh A, Rezaei N. MicroRNA machinery in Parkinson’s disease: a platform for neurodegenerative diseases. Expert Rev Neurother. 2015;17:1–27. doi: 10.1586/14737175.2015.1114886. - DOI - PubMed

[10] Saghazadeh A, Rezaei N. MicroRNA machinery in Parkinson’s disease: a platform for neurodegenerative diseases. Expert Rev Neurother. 2015;17:1–27. doi: 10.1586/14737175.2015.1114886. - DOI - PubMed

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Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease

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Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease

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