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. 2017 Aug 18;19(16):4391-4394.
doi: 10.1021/acs.orglett.7b02126. Epub 2017 Aug 1.

Total Synthesis and Structural Assignment of Curvicollide C

Valeska von Kiedrowski  1 , Florian Quentin  1 , Martin Hiersemann  1
Affiliations

Total Synthesis and Structural Assignment of Curvicollide C

Valeska von Kiedrowski et al. Org Lett. .

Abstract

The first total synthesis of (+)-curvicollide C has been accomplished. Cross-metathesis and Julia-Kocienski olefination were instrumental in the synthesis of 1,3-diene segments and allowed for a ternary-convergent synthetic design. A full structural assignment is proposed for (-)-curvicollide C, a uniquely structured polyketide of fungal origin.

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