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Comment
. 2017 Sep-Oct;10(5):1011-1012.
doi: 10.1016/j.brs.2017.07.008. Epub 2017 Jul 24.

Quantitative reassessment of safety limits of tDCS for two animal studies

Pratik Y Chhatbar  1 , Mark S George  2 , Steven A Kautz  3 , Wuwei Feng  4
Affiliations
Comment

Quantitative reassessment of safety limits of tDCS for two animal studies

Pratik Y Chhatbar et al. Brain Stimul. 2017 Sep-Oct.
No abstract available

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Figures

Figure 1
Figure 1. Comparison of brain lesion threshold between Liebetanz et al. 2009 and Jackson et al. 2017 along with conventional human tDCS dose with the highest dose with evidence of safety on humans
(A) Charge density plot shows that lesion threshold of Jackson et al. 2017 (72.0 kC/m2) is higher than Liebetanz et al. 2009 (52.4 kC/m2), with much smaller charge densities for typical human studies. (B) Charge delivery per unit volume of the brain (arbitrary, assuming 2000× human to rat brain volume ratio) show almost an order of magnitude higher lesion threshold by Jackson et al. 2017 (1.80 C) when compared with Liebetanz et al. 2009 (0.18 C). Given the much bigger size of the human brain, the total charge delivered to the human brain is much smaller when compared with the rat brain. Note the logarithmic scale on the azimuth in both the plots.
See this image and copyright information in PMC

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References

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