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Case Reports
. 2017 Dec;72(6):1028-1029.
doi: 10.1016/j.eururo.2017.07.022. Epub 2017 Jul 29.

Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer

Rahul Aggarwal  1 , Daniel B Vigneron  2 , John Kurhanewicz  2
Affiliations
Case Reports

Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer

Rahul Aggarwal et al. Eur Urol. 2017 Dec.
No abstract available

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Conflict of interest statement

Conflicts of interest: The authors have nothing to disclose.

Figures

Fig. 1
Fig. 1
Representative axial T2-weighted (T2W) anatomic image and corresponding water apparent diffusion coefficient (ADC) image and T2W image with an overlaid pyruvate-to-lactate metabolic flux (kPL) image and corresponding hyperpolarized (HP) 13C spectral array (SA) for a 52-yr-old prostate cancer patient with extensive high-grade prostate cancer (A) before therapy and (B) 6 wk after initiation of androgen ablation and chemotherapy. Before treatment, the region of prostate cancer can be clearly seen (red arrows) as a reduction in signal on the T2W and ADC images, and increased HP lactate and associated kPL flux on HP 13C MRI. After initiation of androgen deprivation therapy there was a significant reduction in reduction in HP lactate and kPL to normal levels, with only a modest treatment effect on prostate volume and ADC.
See this image and copyright information in PMC

References

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    1. Nelson SJ, Kurhanewicz J, Vigneron DB, et al. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-13C]pyruvate. Sci Transl Med. 2013;14:198ra108. - PMC - PubMed

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