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Comment
. 2017 Aug 15;114(33):8678-8680.
doi: 10.1073/pnas.1710943114. Epub 2017 Aug 1.

Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes

Alaattin Kaya  1 , Marco Mariotti  1 , Vadim N Gladyshev  2
Affiliations
Comment

Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes

Alaattin Kaya et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Molecular function and evolution of Ccps. (A) Model depicting the proposed function of Ccp under anoxic conditions, wherein this enzyme uses H2O2 as a terminal electron acceptor to support anoxic respiration. The reduced form of Ccp is generated by menaquinone (MQ) rather than ubiquinone (Q). Under oxic conditions, electron flow (red arrows) represents respiration with O2 as the electron acceptor. (B) Protein tree built from an alignment of Ccp sequences together with similar proteins identified in eukaryotic and prokaryotic genomes. Background colors are used to indicate protein families. Eukaryotic and prokaryotic Ccps do not seem to cluster together.
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Comment on

References

    1. Khademian M, Imlay JA. Escherichia coli cytochrome c peroxidase is a respiratory oxidase that enables the use of hydrogen peroxide as and terminal electron acceptor. Proc Natl Acad Sci USA. 2017;114:E6922–E6931. - PMC - PubMed
    1. Sies H. Oxidative stress: Oxidants and antioxidants. Exp Physiol. 1997;82:291–295. - PubMed
    1. Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol. 2014;24:R453–R462. - PMC - PubMed
    1. Holmström KM, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol. 2014;15:411–421. - PubMed
    1. Giorgio M, Trinei M, Migliaccio E, Pelicci PG. Hydrogen peroxide: A metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol. 2007;8:722–728. - PubMed

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