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Comment
. 2018 Apr;67(4):778-779.
doi: 10.1136/gutjnl-2017-314792. Epub 2017 Aug 1.

Faecal microbiota composition associates with abdominal pain in the general population

Fatemeh Hadizadeh  1   2 , Ferdinando Bonfiglio  1   3 , Meriem Belheouane  4   5 , Marie Vallier  4   5 , Sascha Sauer  6 , Corinna Bang  7 , Luis Bujanda  3   8 , Anna Andreasson  9   10 , Lars Agreus  9 , Lars Engstrand  11   12 , Nicholas J Talley  9   13   14   15 , Joseph Rafter  1 , John F Baines  4   5 , Susanna Walter  16 , Andre Franke  7 , Mauro D'Amato  3   17   18
Affiliations
Comment

Faecal microbiota composition associates with abdominal pain in the general population

Fatemeh Hadizadeh et al. Gut. 2018 Apr.
No abstract available

Keywords: abdominal pain; colonic microflora.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Faecal microbiota β-diversity associates with abdominal pain. Top: Heat map of Spearman correlation between pain indices and faecal microbiota β-diversity, based on principal coordinate analysis applied to Bray-Curtis and Jaccard matrices at the level of genera (Genera) and operational taxonomic units with 97% sequence similarity (OTU 97%). The first three principal coordinates (PC) are reported (PC1, PC2 and PC3) and significant correlations (false discovery rate < 0.1) are highlighted by a black frame. Bottom: Box plots of PC scores in cases and controls, where significant differences (corrected p value<0.05) are highlighted with *.
Figure 2
Figure 2
Faecal microbiota enterotype distribution differs in individuals with abdominal pain compared with controls. Principal component analysis (left) and relative distribution (right) of enterotypes according to the presence (case) or absence (control) of abdominal pain. Participants were classified into three enterotypes primarily characterised by unclassified Ruminococcaceae, Prevotella or Bacteroides. *p<0.05.
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References

    1. Simrén M, Törnblom H, Palsson OS, et al. . Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts. Gut 2018;67:255–62. 10.1136/gutjnl-2016-312361 - DOI - PubMed
    1. Aguilera M, Vergara P, Martínez V. Stress and antibiotics alter luminal and wall-adhered microbiota and enhance the local expression of visceral sensory-related systems in mice. Neurogastroenterol Motil 2013;25:e515–e529. 10.1111/nmo.12154 - DOI - PubMed
    1. Crouzet L, Gaultier E, Del’Homme C, et al. . The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota. Neurogastroenterol Motil 2013;25:e272–e282. 10.1111/nmo.12103 - DOI - PubMed
    1. Jalanka-Tuovinen J, Salonen A, Nikkilä J, et al. . Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One 2011;6:e23035 10.1371/journal.pone.0023035 - DOI - PMC - PubMed
    1. Kjellström L, Molinder H, Agréus L, et al. . A randomly selected population sample undergoing colonoscopy: prevalence of the irritable bowel syndrome and the impact of selection factors. Eur J Gastroenterol Hepatol 2014;26:268–75. 10.1097/MEG.0000000000000024 - DOI - PubMed

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