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Review
. 2017 Aug 2;18(8):1684.
doi: 10.3390/ijms18081684.

Mechanosensitive miRNAs and Bone Formation

Zhihao Chen  1   2   3 , Yan Zhang  4   5   6 , Chao Liang  7   8 , Lei Chen  9   10   11 , Ge Zhang  12   13 , Airong Qian  14   15   16
Affiliations
Review

Mechanosensitive miRNAs and Bone Formation

Zhihao Chen et al. Int J Mol Sci. .

Abstract

Mechanical stimuli are required for the maintenance of skeletal integrity and bone mass. An increasing amount of evidence indicates that multiple regulators (e.g., hormone, cytoskeleton proteins and signaling pathways) are involved in the mechanical stimuli modulating the activities of osteogenic cells and the process of bone formation. Significantly, recent studies have showed that several microRNAs (miRNAs) were sensitive to various mechanical stimuli and played a crucial role in osteogenic differentiation and bone formation. However, the functional roles and further mechanisms of mechanosensitive miRNAs in bone formation are not yet completely understood. This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli.

Keywords: bone formation; mechanical stimuli; mechanosensitive miRNAs; osteogenic differentiation.

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Conflict of interest statement

The authors declare no conflict of interest.

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