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Review
. 2017 Aug;96(31):e7663.
doi: 10.1097/MD.0000000000007663.

Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: A meta-analysis

Lin-Lin Cao  1 , Xiaoxu Song, Lin Pei, Lianhua Liu, Hui Wang, Mei Jia
Affiliations
Review

Histone deacetylase HDAC1 expression correlates with the progression and prognosis of lung cancer: A meta-analysis

Lin-Lin Cao et al. Medicine (Baltimore). 2017 Aug.

Abstract

Background: Histone deacetylase 1 (HDAC1) is an important epigenetic factor, and is thought to be associated with the progression and prognosis of some types of cancer. HDAC1 has been reported to be overexpressed in lung cancer, but the correlation between HDAC1 overexpression and the clinical features or prognosis of lung cancer is controversial. In this study, we investigated the potential association between HDAC1 and lung cancer.

Materials and methods: Embase, Web of Science, PubMed, and other sources were searched for relevant studies. Pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence interval (CI) were calculated to evaluate the association of HDAC1 with lung cancer risk.

Results: Eight eligible studies were included in the final meta-analysis. We found that HDAC1 mRNA or protein expression was closely associated with the differentiation grade of lung cancer (OR = 2.36, 95% CI = 1.14-4.87, P = .02). In addition, the protein expression level of HDAC1 in squamous cell carcinoma was higher than that in adenocarcinoma (OR = 1.81, 95% CI = 1.13-2.90, P = .01). Finally, HDAC1 mRNA or protein expression was negatively correlated with the overall survival rate of patients with lung cancer (HR = 2.40, 95% CI = 1.48-3.88, P = .0004).

Conclusion: In this meta-analysis, our results suggest that HDAC1 may serve as a good diagnostic and prognostic marker for lung cancer.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Methodological flow chart of study selection.
Figure 2
Figure 2
Forest plot of odds ratio (OR). Comparison of the expression level of histone deacetylase 1 (HDAC1) between tumors >3 cm and tumors ≤3 cm. CI = confidence interval.
Figure 3
Figure 3
Forest plot of odds ratio (OR). Association between histone deacetylase 1 (HDAC1) expression and tumor stage in lung cancer. CI = confidence interval.
Figure 4
Figure 4
Forest plot of odds ratio (OR). Association between histone deacetylase 1 (HDAC1) expression and tumor differentiation grade in lung cancer. CI = confidence interval.
Figure 5
Figure 5
Forest plot of odds ratio (OR). Association between histone deacetylase 1 (HDAC1) expression and lymph node metastasis state in lung cancer. CI = confidence interval.
Figure 6
Figure 6
Forest plot of odds ratio (OR). Association between histone deacetylase 1 (HDAC1) expression and pathological subtypes of lung cancer. CI = confidence interval.
Figure 7
Figure 7
Forest plot of hazard ratio (HR). Association between histone deacetylase 1 (HDAC1) expression and the overall survival of lung cancer patients. CI = confidence interval.
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