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Comment
. 2017 Aug 1;26(2):289-291.
doi: 10.1016/j.cmet.2017.07.014.

Once Blind, Now We See GLP-1 Molecular Action

John P Mayer  1 , Matthias H Tschöp  2 , Richard D DiMarchi  3
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Once Blind, Now We See GLP-1 Molecular Action

John P Mayer et al. Cell Metab. .
Free article

Abstract

The macromolecular mechanics of GLP-1 with its cell surface receptor came into focus as two landmark publications recently published in Nature collectively herald advancement in structure-based design for a receptor class of great therapeutic importance (Jazayeri et al., 2017; Zhang et al., 2017).

Keywords: GLP-1; GPCR family B; cryoelectron microscopy; incretin; structure-based drug design.

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