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Review
. 2017 Jul 18:8:474.
doi: 10.3389/fphar.2017.00474. eCollection 2017.

Metabolomics and Integrative Omics for the Development of Thai Traditional Medicine

Sakda Khoomrung  1   2   3 , Kwanjeera Wanichthanarak  1   2 , Intawat Nookaew  1   3   4 , Onusa Thamsermsang  1 , Patcharamon Seubnooch  5 , Tawee Laohapand  1 , Pravit Akarasereenont  1   2   5
Affiliations
Review

Metabolomics and Integrative Omics for the Development of Thai Traditional Medicine

Sakda Khoomrung et al. Front Pharmacol. .

Abstract

In recent years, interest in studies of traditional medicine in Asian and African countries has gradually increased due to its potential to complement modern medicine. In this review, we provide an overview of Thai traditional medicine (TTM) current development, and ongoing research activities of TTM related to metabolomics. This review will also focus on three important elements of systems biology analysis of TTM including analytical techniques, statistical approaches and bioinformatics tools for handling and analyzing untargeted metabolomics data. The main objective of this data analysis is to gain a comprehensive understanding of the system wide effects that TTM has on individuals. Furthermore, potential applications of metabolomics and systems medicine in TTM will also be discussed.

Keywords: Thai traditional medicine; analytical chemistry; herbal medicines; integrative omics; metabolomics.

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Figures

Figure 1
Figure 1
Overview of the steps involved in untargeted metabolomics.
Figure 2
Figure 2
Overview of the steps involved in targeted metabolomics.
Figure 3
Figure 3
Integration of multi-omics and clinical data into TTM. (A) Herbal plants and herbal medicines. (B) Chemical characterization of herbal plants, herbal medicines, and biofluids using targeted and untargeted metabolomics. (C) Clinical trial of herbal plants and herbal medicines by cell lines, animal, or human models. (D) Biofluid for metabolome analysis. (E) Integrative analysis of different omics data and clinical data. (F) Systems biology network. (G) Individualized data.
See this image and copyright information in PMC

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