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Review
. 2017 Oct;296(4):653-660.
doi: 10.1007/s00404-017-4478-6. Epub 2017 Aug 2.

Primary ovarian Burkitt's lymphoma: a rare oncological problem in gynaecology: a review of literature

Anna Stepniak  1 , Piotr Czuczwar  2 , Piotr Szkodziak  1 , Ewa Wozniakowska  1 , Slawomir Wozniak  1 , Tomasz Paszkowski  1
Affiliations
Review

Primary ovarian Burkitt's lymphoma: a rare oncological problem in gynaecology: a review of literature

Anna Stepniak et al. Arch Gynecol Obstet. 2017 Oct.

Abstract

Purpose: This review presents the information about epidemiology, clinical manifestation, diagnosis and treatment of primary ovarian Burkitt's lymphoma (BL), including a literature search of available BL cases. The purpose of this review is to draw clinicians' attention to the possibility of ovarian BL occurrence, which may be important in the differential diagnosis of ovarian tumours.

Methods: PubMed and Web of Science databases were searched using the keywords ''Burkitt's'', ''Lymphoma'', ''Ovarian'', ''Primary'', ''Burkitt's lymphoma''. Only cases with histopathologically confirmed diagnosis of primary ovarian BL were included in this review.

Results: Fifty articles, reporting cases with an ovarian manifestation of primary non-Hodgkin's lymphoma, were found. Twenty-one cases with a histopathologically confirmed BL were evaluated to compare various manifestations, treatment and prognosis in ovarian BL.

Conclusions: Primary ovarian BL is a rare condition, included in the entity of non-Hodgkin lymphoma. The tumour can occur uni- or bilaterally in the ovaries with major symptoms such as abdominal pain or a large abdominal mass. Differential diagnosis, based on imaging features and pathological examination of the specimens, is essential for further treatment due to various aetiology of ovarian tumours. Although most of the patients suffering from ovarian BL underwent surgery after the ovarian tumour had been detected, surgical treatment is not the treatment of choice in patients with ovarian lymphoma. The mainstay of therapy is chemotherapy without further surgery. The prognosis is better if the chemotherapy protocol is more aggressive and followed by prophylactic central nervous system chemotherapy. Nowadays, multiagent protocols are administered, which improves the survival rate.

Keywords: Burkitt’s lymphoma; Non-Hodgkin lymphoma; Ovarian tumour; Primary ovarian Burkitt’s lymphoma.

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Conflict of interest statement

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

We declare that we have no conflict of interest.

Figures

Fig. 1
Fig. 1
Factors suggestive of primary ovarian Burkitt’s lymphoma
See this image and copyright information in PMC

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