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Case Reports
. 2018 Jan;33(1):125-127.
doi: 10.1007/s11606-017-4135-6. Epub 2017 Aug 2.

Checkpoint Inhibitor-Associated Hypophysitis

Lee-Shing Chang  1 , Maria A Yialamas  2
Affiliations
Case Reports

Checkpoint Inhibitor-Associated Hypophysitis

Lee-Shing Chang et al. J Gen Intern Med. 2018 Jan.
No abstract available

Keywords: checkpoint inhibitors; hypophysitis; immunotherapy; ipilimumab; nivolumab.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Coronal views of the patient’s brain on MRI. A Before ipilimumab and nivolumab initiation. B Five months after ipilimumab and nivolumab initiation. C Inset of panel A, with a normal-sized pituitary gland (arrow) and pituitary stalk. D Inset of panel B, with diffuse enlargement of the pituitary gland (arrow) and thickening of the pituitary stalk.
Figure 2
Figure 2
Sagittal views of the patient’s brain on MRI. A Before ipilimumab and nivolumab initiation. The patient had a preexisting parafalcine meningioma (asterisk). B Five months after ipilimumab and nivolumab initiation. C Inset of panel A, with a normal-sized pituitary gland (arrow) and pituitary stalk. D Inset of panel B, with diffuse enlargement of the pituitary gland (arrow) and thickening of the pituitary stalk.
See this image and copyright information in PMC

References

    1. Joshi MN, Whitelaw BC, Palomar MT, Wu Y, Carroll PV. Immune checkpoint inhibitor-related hypophysitis and endocrine dysfunction: clinical review. Clin Endocrinol (Oxf) 2016;85:331–9. doi: 10.1111/cen.13063. - DOI - PubMed
    1. Faje A. Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights. Pituitary. 2016;19:82–92. doi: 10.1007/s11102-015-0671-4. - DOI - PubMed

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