Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Sep 17;16(18):1635-1636.
doi: 10.1080/15384101.2017.1360633. Epub 2017 Aug 3.

Nicotinic acid: A case for a vitamin that moonlights for cancer?

Francesco Piacente  1 , Irene Caffa  1 , Alessio Nencioni  1   2
Affiliations
Editorial

Nicotinic acid: A case for a vitamin that moonlights for cancer?

Francesco Piacente et al. Cell Cycle. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Biosynthetic pathway of NAD+ production starting from Na. Nicotinic acid (Na) is converted to NAD+ through the 3-step Preiss-Handler pathway. NAPRT catalyzes the formation of nicotinic acid mononucleotide (NaMN) by adding a 5-phosphoribose group (P-ribose) from 5-phosphoribosyl-1-pyrophosphate to Na. NaMN is converted to nicotinic acid adenine dinucleotide (NaAD+) by nicotinamide mononucleotide adenylyltransferase 1/3 (NMNAT1–3). Finally, NAD+ synthase 1 (NADSYN1) converts NaAD+ to NAD+. The NAPRT gene is amplified and overexpressed in a subset of tumors, including ovarian, breast, pancreatic and prostate cancer. NAPRT-derived NAD+ supports the activity of DNA repair enzymes, such as PARP1/2, which, in turn, may be especially important in cancer cells with defective homologous recombination DNA repair to avoid catastrophic DNA damage. In addition, NAPRT-mediated NAD+ production turns out to be especially important for replenishing the mitochondrial NAD+ stores, for promoting OXPHOS, ATP synthesis, and protein synthesis and, ultimately, for regulating cell size. PAR: poly (ADP-ribose).
See this image and copyright information in PMC

Comment on

References

    1. Bogan KL, Brenner C.. Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443 - DOI - PubMed
    1. Kirkland JB. Niacin requirements for genomic stability. Mutat Res. 2012;733:14-20. doi: 10.1016/j.mrfmmm.2011.11.008. PMID:22138132 - DOI - PubMed
    1. Bruzzone S, Daniele Parenti M, Grozio A, Ballestrero A, Bauer I, Del Rio A, Nencioni A.. Rejuvenating sirtuins: The rise of a new family of cancer drug targets. Curr Pharm Des. 2013;19:614-23. doi: 10.2174/138161213804581954. PMID:23016857 - DOI - PMC - PubMed
    1. Piacente F, Caffa I, Ravera S, Sociali G, Passalacqua M, Vellone VG, Becherini P, Reverberi D, Monacelli F, Ballestrero A, Odetti P, Cagnetta A, Cea M, Nahimana A, Duchosal M, Bruzzone S, Nencioni A.. Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors, and DNA repair. Cancer Res. 2017;77(14):3857-69. pii: canres.3079.2016. doi: 10.1158/0008-5472.CAN-16-3079. PMID:28507103 - DOI - PubMed
    1. Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N.. The cBio Cancer Genomics Portal: An open platform for exploring multidimensional cancer genomics Data. Cancer Discov. 2012;2:401-4. doi: 10.1158/2159-8290.CD-12-0095. PMID:22588877 - DOI - PMC - PubMed