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. 2017 Aug;98(8):2011-2016.
doi: 10.1099/jgv.0.000877. Epub 2017 Aug 4.

Assessing evidence for avian-to-human transmission of influenza A/H9N2 virus in rural farming communities in northern Vietnam

Le Nguyen Minh Hoa  1 , Nguyen Anh Tuan  1 , Pham Ha My  1 , Tran Thi Kieu Huong  1 , Nguyen Thi Yen Chi  1 , Trang Thi Hau Thu  1 , Juan Carrique-Mas  1 , Mai Thuy Duong  2 , Nguyen Dang Tho  2 , Nguyen Dang Hoang  2 , To Long Thanh  2 , Nguyen Thi Diep  3 , Nguyen van Duong  4 , Tran Khanh Toan  5 , Trinh Son Tung  1   6 , Le Quynh Mai  6 , Munir Iqbal  7 , Heiman Wertheim  1   8 , H Rogier van Doorn  1   9 , Juliet E Bryant  1   9 , The Vizions Consortium
Affiliations

Assessing evidence for avian-to-human transmission of influenza A/H9N2 virus in rural farming communities in northern Vietnam

Le Nguyen Minh Hoa et al. J Gen Virol. 2017 Aug.

Abstract

Rural farming communities in northern Vietnam do not routinely practice vaccination for influenza A viruses (IAV) for either humans or poultry, which enables us to study transmission intensity via seroepidemiology. Using samples from a longitudinal cohort of farming households, we determined the number of symptomatic and asymptomatic human infections for seasonal IAV and avian A/H9 over 2 years. As expected, we detected virologically confirmed acute cases of seasonal IAV in humans, as well as large numbers of subclinical seroconversions to A/H1pdm [55/265 (21 %)], A/H3 [95/265 (36 %)] and A/H9 [24/265 (9 %)]. Five of the A/H9 human seroconverters likely represented true infections rather than heterosubtypic immunity, because the individuals seroconverted solely to A/H9. Among co-located poultry, we found significantly higher seroprevalance for A/H5 compared to A/H9 in both chickens and ducks [for northern study sites overall, 337/1105 (30.5 %) seropositive for A/H5 and 123/1105 (11.1 %) seropositive for A/H9].

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Figures

Fig. 1.
Fig. 1.
Geometric mean antibody titres (GMT) for A/H9 seropositivity at three time points, stratified by age group.
See this image and copyright information in PMC

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