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. 2017 Dec 1;3(12):1735-1736.
doi: 10.1001/jamaoncol.2017.1355.

Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging

Mandy L Ballinger  1 , Nicholas J Ferris  2 , Kate Moodie  3 , Gillian Mitchell  4 , Sue Shanley  4 , Paul A James  4   5 , David M Thomas  1
Affiliations

Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging

Mandy L Ballinger et al. JAMA Oncol. .

Abstract

This prospective study of surveillance strategies uses a whole-body screening program, including whole-body magnetic resonance imaging, in carriers of germline mutations in TP53.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

References

    1. Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250(4985):1233-1238. - PubMed
    1. Ruijs MW, Verhoef S, Rookus MA, et al. TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes. J Med Genet. 2010;47(6):421-428. - PubMed
    1. Villani A, Shore A, Wasserman JD, et al. Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study. Lancet Oncol. 2016;17(9):1295-1305. - PubMed

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