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. 2016 Mar 24;9(4):225.
doi: 10.3390/ma9040225.

Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification

Dominika Kozon  1   2 , Kai Zheng  3 , Elena Boccardi  4 , Yufang Liu  5 , Liliana Liverani  6 , Aldo R Boccaccini  7
Affiliations

Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification

Dominika Kozon et al. Materials (Basel). .

Abstract

Monodispersed spherical Ag-doped bioactive glass nanoparticles (Ag-BGNs) were synthesized by a modified Stöber method combined with surface modification. The surface modification was carried out at 25, 60, and 80 °C, respectively, to investigate the influence of processing temperature on particle properties. Energy-dispersive X-ray spectroscopy (EDS) results indicated that higher temperatures facilitate the incorporation of Ag. Hydroxyapatite (HA) formation on Ag-BGNs was detected upon immersion of the particles in simulated body fluid for 7 days, which indicated that Ag-BGNs maintained high bioactivity after surface modification. The conducted antibacterial assay confirmed that Ag-BGNs had an antibacterial effect on E. coli. The above results thereby suggest that surface modification is an effective way to incorporate Ag into BGNs and that the modified BGNs can remain monodispersed as well as exhibit bioactivity and antibacterial capability for biomedical applications.

Keywords: antibacterial activity; bioactive glass nanoparticle; bioactivity; silver; surface modification.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scanning electron microscopy (SEM) images of samples before and after soaking in SBF for 7 days. (A) BGNs; (B) Ag-25; (C) Ag-60; (D) Ag-80; (E) BGNs 7d; (F) Ag-25 7d; (G) Ag-60 7d; (H) Ag-80 7d. Inserted are the corresponding energy-dispersive X-ray spectroscopy (EDS) results.
Figure 2
Figure 2
(a) X-ray diffraction (XRD) patterns of BGNs and surface modified Ag-BGNs; (b) Fourier-transform infrared spectroscopy (FTIR) spectra of Ag-BGNs before and after soak in SBF for 7 days.
Figure 3
Figure 3
Antibacterial activity of BGNs and Ag-BGNs (Ag-25) towards B. subtilis and E. coli.
See this image and copyright information in PMC

References

    1. Hench L.L. Opening paper 2015—Some comments on bioglass: Four eras of discovery and development. Biomed. Glas. 2015;1:1–11. doi: 10.1515/bglass-2015-0001. - DOI
    1. Miguez-Pacheco V., Hench L.L., Boccaccini A.R. Bioactive glasses beyond bone and teeth: Emerging applications in contact with soft tissues. Acta Biomater. 2015;13:1–15. doi: 10.1016/j.actbio.2014.11.004. - DOI - PubMed
    1. Hoppe A., Güldal N.S., Boccaccini A.R. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials. 2011;32:2757–2774. doi: 10.1016/j.biomaterials.2011.01.004. - DOI - PubMed
    1. Erol-Taygun M., Zheng K., Boccaccini A.R. Nanoscale bioactive glasses in medical applications. Int. J. Appl. Glas. Sci. 2013;4:136–148. doi: 10.1111/ijag.12029. - DOI
    1. Brinker C.J., Scherer G.W. Sol-Gel Science: The Physics and Chemistry of Sol-Gel Processing. Academic Press; San Diego, CA, USA: 1990.