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. 2017 Aug 3;18(1):95.
doi: 10.1186/s12889-017-4651-7.

Epidemiology of Humanpapilloma virus infection among women in Fujian, China

Conglian Wu  1   2 , Xianjin Zhu  1 , Yanli Kang  1 , Yinping Cao  1 , Pingxia Lu  1 , Wenjuan Zhou  1 , Hong Zhou  1 , Yang Zhang  1 , Yanfang Song  3
Affiliations

Epidemiology of Humanpapilloma virus infection among women in Fujian, China

Conglian Wu et al. BMC Public Health. .

Erratum in

  • Erratum to: BMC Public Health, Vol. 18.
    [No authors listed] [No authors listed] BMC Public Health. 2017 Sep 22;17(1):736. doi: 10.1186/s12889-017-4709-6. BMC Public Health. 2017. PMID: 28938882 Free PMC article. No abstract available.

Abstract

Background: Human papillomavirus (HPV) infection is the main etiological factor for the development of cervical cancer. Here we assessed the prevalence and distribution of HPV genotypes in Fujian population.

Methods: A total of 8678 women aging from 17 to 84 years olds were recruited from the Fujian Medical University Union Hospital in Fujian Province. Every woman had a face-to-face interview. Cervical samples were collected from each participant and HPV screening was conducted using microarray hybridization.

Results: Our study showed that the HPV prevalence in Fujian province was 38.3%. Among the positive individuals, 70.6% were detected for single HPV infection, 29.4% for multiple HPV infections. Further analysis showed that the prevalence of HPV infection significantly increased from 2009 to 2015. The four most common high risk human papillomavirus (HR-HPV) genotypes were HPV16 (8.5%), HPV52 (7.9%), HPV58 (6.2%), HPV 53 (3.5%), collectively accounting for 60.5% of all detected HPV infection. Age subgroup analysis showed two peaks for the frequencies of overall and multiple HPV infections, one for the group of women under 25 years old, and the other for the group over 55 years old.

Conclusions: HPV infection is becoming serious in Fujian province, which indicates the imperative to implement a HPV vaccination and screening program for this region.

Keywords: Cervical cancer; Fujian; Genotyping; Human papillomavirus (HPV); Prevalence.

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Conflict of interest statement

Ethics approval and consent to participate

These studies were performed in accordance with ethical guidelines under the protocols approved by the Institutional Medical Ethics Review Board of Affiliated Union Hospital of Fujian Medical University, Fuzhou, China. All adults who participated in the study signed a consent form.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Distribution of different HPV genotypes in Fujian province. HPV genotypes, including 6 low-risk (LR) genotypes (6, 11, 42, 43 and 44, CP8304), and 15 high-risk (HR) genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68) were detected by flow-through hybridization and gene chip by HybriMax
Fig. 2
Fig. 2
Specific age-related prevalence of HPV infection. a The age-specific prevalence of total HPV, single HPV, and multiple HPV. b The age-specific prevalence of single HR-HPV, and single LR-HPV. c The age-specific prevalence of the four most prevalent HR-HPV genotypes (HPV 16, 52, 58 and 53) in Fujian province
See this image and copyright information in PMC

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