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. 2017 Sep:145:184-196.
doi: 10.1016/j.antiviral.2017.07.017. Epub 2017 Aug 1.

Highlights of the 30th International Conference on Antiviral Research

Graciela Andrei  1 , Kara Carter  2 , Zlatko Janeba  3 , Aruna Sampath  4 , Luis M Schang  5 , E Bart Tarbet  6 , R Anthony Vere Hodge  7 , Mike Bray  8 , José A Esté  9
Affiliations

Highlights of the 30th International Conference on Antiviral Research

Graciela Andrei et al. Antiviral Res. 2017 Sep.

Abstract

The 30th International Conference on Antiviral Research (ICAR) was held in Atlanta, GA, USA from May 18 to 21, 2017. This report provides an account of award lectures, invited keynote addresses and oral presentations during the meeting. The 2017 Gertrude Elion Memorial Lecture Award by Michael Sofia highlighted one of the most important accomplishments in recent drug discovery in antiviral research, the identification of the hepatitis C virus direct-acting antiviral sofosbuvir and new alternatives to combat hepatitis B virus (HBV) infection. The Antonín Holý Lecture Award by David Chu on medicinal chemistry provided an overview of early developments of nucleoside analogs for the treatment of HIV and varicella zoster virus infection and how this knowledge serves to develop new drugs targeting HBV. Priscilla Yang gave the first ISAR Women in Science lecture. She reported on pharmacological validation of new antiviral targets for dengue, Zika and other flaviviruses. The William Prusoff Young Investigator Lecture Award by Maaike Everts described the Alabama Drug Discovery Alliance and the Antiviral Drug Discovery and Development Consortium, and how they are helping to accelerate the development of new antivirals. The 30th ICAR was a success in promoting new discoveries in antiviral drug development and research. The 31st ICAR will be held in Porto, Portugal, June 11-15, 2018.

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Figures

Fig. 1
Fig. 1
The long road to a cure of chronic hepatitis C.
Fig. 2
Fig. 2
A cure yet to be realized: chronic hepatitis B.
Fig. 3
Fig. 3
Chemical structures of some of the compounds discussed during Dr. David Chu's lecture.
Fig. 4
Fig. 4
Structure of the dengue virus envelope glycoprotein, showing location of a ligand-binding pocket. Left: the pre-fusion dimer ribbon structure, with zoom showing detergent bound in the pocket. Right: monomers of the pre-fusion and post-fusion forms of E. Adapted from (Modis et al., 2003, Modis et al., 2004).
Fig. 5
Fig. 5
The structure of the Antiviral Drug Discovery and Development Consortium (AD3C) highlights the interconnections among the core groups and the projects, and the facilitating role of the administrative core (Core A) in moving projects forward through the pipeline.
See this image and copyright information in PMC

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