Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 28:4:13.
doi: 10.1186/s40673-017-0071-9. eCollection 2017.

Cognitive impairment in cerebellar lesions: a logit model based on neuropsychological testing

Eva Bolceková  1 , Matej Mojzeš  2 , Quang Van Tran  2 , Jaromír Kukal  2 , Svatopluk Ostrý  3   4 , Petr Kulišťák  5 , Robert Rusina  1   6
Affiliations

Cognitive impairment in cerebellar lesions: a logit model based on neuropsychological testing

Eva Bolceková et al. Cerebellum Ataxias. .

Abstract

Background: Damage to the cerebellum may lead to motor dysfunctions, but also to the neuropsychological deficits that comprise the Cerebellar Cognitive Affective Syndrome (CCAS). It can affect executive functions, attention, memory, visuospatial functions, language, and emotions. Our goal was to determine which neuropsychological tests could be effectively used to identify this syndrome during a short examination.

Methods: Twenty-five patients with an isolated cerebellar lesion and 25 matched healthy controls were examined using an extensive neuropsychological battery.

Results: Logistic regression models and sub-models were computed for individual tests, as well as for the full battery. The best results were produced by a model combining patient education level, the number of errors on the California Verbal Learning Test, and time on Prague Stroop Test (Dots).

Conclusions: Based on the results, we suggest that a condensed battery of neuropsychological tests can be used to detect CCAS. The tests are easy to administer and could be helpful in both research and clinical settings.

Keywords: Attention; Cerebellum; Cognition disorders; Executive function; Logistic models; Neuropsychological tests.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Ethics Committee of the Institute for Clinical and Experimental Medicine and Thomayer Hospital n. 645/13 (A 13–04-02).

Consent for publication

All participants signed an informed consent with anonymous publication of their data.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Cerebellar lesions of the patients
Fig. 2
Fig. 2
Boxplot of the distribution of control subjects and patients according to the best logit model. The value on y-axis represents the logit of the model. Ends of the whiskers represent 1.5 interquartile ranges (IQR)
See this image and copyright information in PMC

References

    1. Leiner HC, Leiner AL, Dow RS. Does the cerebellum contribute to mental skills? Behav Neurosci. 1986;100:443–454. doi: 10.1037/0735-7044.100.4.443. - DOI - PubMed
    1. Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561–579. doi: 10.1093/brain/121.4.561. - DOI - PubMed
    1. Manto M, Mariën P. Schmahmann’s syndrome-identification of the third cornerstone of clinical ataxiology. Cerebellum Ataxias. 2015;2:2. doi: 10.1186/s40673-015-0023-1. - DOI - PMC - PubMed
    1. O’Halloran CJ, Kinsella GJ, Storey E. The cerebellum and neuropsychological functioning: a critical review. J Clin Exp Neuropsychol. 2012;34:35–56. doi: 10.1080/13803395.2011.614599. - DOI - PubMed
    1. Bellebaum C, Daum I. Cerebellar involvement in executive control. Cerebellum. 2007;6:184–192. doi: 10.1080/14734220601169707. - DOI - PubMed

LinkOut - more resources