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Review
. 2017 Sep 13;117(17):11269-11301.
doi: 10.1021/acs.chemrev.7b00077. Epub 2017 Aug 4.

Small-Molecule Modulation of Protein Homeostasis

George M Burslem  1 , Craig M Crews  1
Affiliations
Review

Small-Molecule Modulation of Protein Homeostasis

George M Burslem et al. Chem Rev. .

Abstract

Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with small molecules and compare the various systems available.

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