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. 2018 Apr;32(7):767-772.
doi: 10.1080/14786419.2017.1359172. Epub 2017 Aug 4.

Balanochalcone, a new chalcone from Balanophora laxiflora Hemsl

Dang Ngoc Quang  1 , Tran Cong So  1 , Nguyen Thi Phuong Thanh  1 , Le Thi Phuong Hoa  2 , Pham Huu Dien  1 , Truong Minh Luong  1 , Nguyen Quang Tung  3 , Le Duc Long  3 , Tran Duc Dai  4 , Nguyen Quyet Tien  4
Affiliations

Balanochalcone, a new chalcone from Balanophora laxiflora Hemsl

Dang Ngoc Quang et al. Nat Prod Res. 2018 Apr.

Abstract

A new chalcone named as balanochalcone (1) together with eight known compounds, methyl caffeate (2), β-hydroxydihydrochalcone (3), methyl gallate (4), dimethyl-6,9,10-trihydroxybenzo[kl]xanthene-1,2-dicarboxylate (5), p-coumaric acid (6), quercetin (7), scopoletin (8) and pinoresinol (9) have been isolated from the ethyl acetate extract of Vietnamese Balanophora laxiflora Hemsl. Their structures were characterised by IR, UV, HR-ESI-MS, 1D and 2D NMR and CD spectroscopies. Compounds 2 and 5 showed moderate cytotoxicity against four cancer cell lines, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma). In addition, compounds 1 and 5 showed moderate antioxidant activity.

Keywords: Balanophora laxiflora; antioxidant; chalcone; cytotoxicity.

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