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. 2017 Sep 15:310:26-31.
doi: 10.1016/j.jneuroim.2017.06.004. Epub 2017 Jun 15.

Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease

E Caggiu  1 , K Paulus  2 , G Galleri  2 , G Arru  2 , R Manetti  2 , G P Sechi  2 , L A Sechi  3
Affiliations

Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease

E Caggiu et al. J Neuroimmunol. .

Abstract

Environmental factors are implicated in the development of Parkinson's disease (PD). The aim of this study is to investigate the role of cell-mediated immunity upon a specific immune-stimulation with HSV-1 and human alpha-synuclein homologues peptides by using the intracellular cytokine method on Parkinson's patients and healthy controls. The study showed, for the first time, a specific response to TNF-α CD8, CD4 and NK cells after stimulation in PD patients. Our data show a possible role of the immune system in the pathogenesis of Parkinson's disease, and that HSV-1 infections may lead to a progression of the disease.

Keywords: Autoimmunity; HSV1; Molecular mimicry; Parkinson's disease; Peptides.

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