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. 2018 Jan;28(1):437-445.
doi: 10.1007/s00330-017-4989-3. Epub 2017 Aug 4.

Multi-parametric MRI in cervical cancer: early prediction of response to concurrent chemoradiotherapy in combination with clinical prognostic factors

Wei Yang  1 , Jin Wei Qiang  2 , Hai Ping Tian  3 , Bing Chen  1 , Ai Jun Wang  1 , Jian Guo Zhao  1
Affiliations

Multi-parametric MRI in cervical cancer: early prediction of response to concurrent chemoradiotherapy in combination with clinical prognostic factors

Wei Yang et al. Eur Radiol. 2018 Jan.

Abstract

Objective: To investigate the prediction of response to concurrent chemoradiotherapy (CCRT) through a combination of pretreatment multi-parametric magnetic resonance imaging (MRI) with clinical prognostic factors (CPF) in cervical cancer patients.

Methods: Sixty-five patients underwent conventional MRI, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced MRI (DCE-MRI) before CCRT. The patients were divided into non- and residual tumour groups according to post-treatment MRI. Pretreatment MRI parameters and CPF between the two groups were compared and prognostic factors, optimal thresholds, and predictive performance for post-treatment residual tumour occurrence were estimated.

Results: The residual group showed a lower maximum slope of increase (MSIL) and signal enhancement ratio (SERL) in low-perfusion subregions, a higher apparent diffusion coefficient (ADC) value, and a higher stage than the non-residual tumour group (p < 0.001, p = 0.003, p < 0.001, and p < 0.001, respectively). MSIL and ADC were independent prognostic factors. The combination of both measures improved the diagnostic performance compared with individual MRI parameters. A further combination of these two factors with CPF exhibited the highest predictive performance.

Conclusions: Pretreatment MSIL and ADC were independent prognostic factors for cervical cancer. The predictive capacity of multi-parametric MRI was superior to individual MRI parameters. The combination of multi-parametric MRI with CPF further improved the predictive performance.

Key points: • Pretreatment MSI L and ADC were independent prognostic factors for post-treatment residual tumours. • The residual groups showed lower MSI L , higher ADC and higher stage. • The predictive capacity of multi-parametric MRI was superior to individual MRI parameters. • The combination of multi-parametric MRI with CPF exhibited the highest predictive performance.

Keywords: Cervical cancer; Concurrent chemoradiotherapy; Diffusion-weighted imaging; Dynamic contrast-enhanced MR imaging; Magnetic resonance imaging.

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References

    1. Eur Radiol. 2008 May;18(5):1058-64 - PubMed
    1. Gynecol Oncol. 2010 Feb;116(2):253-61 - PubMed
    1. PLoS One. 2016 Feb 22;11(2):e0149279 - PubMed
    1. Eur J Radiol. 2015 Feb;84(2):242-9 - PubMed
    1. J Cancer Sci Ther. 2012 Sep;4(9):254-259 - PubMed