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Review
. 2017 Dec:42:207-212.
doi: 10.1016/j.jcrc.2017.07.029. Epub 2017 Jul 12.

Hypoxia-inducible-factor-1 in trauma and critical care

Dorian A Bogdanovski  1 , Louis T DiFazio  2 , Anastasia K Bogdanovski  3 , Balázs Csóka  4 , Garrett B Jordan  5 , Elina R Paul  6 , Luca Antonioli  7 , Stefanie A Pilip  8 , Zoltan H Nemeth  9
Affiliations
Review

Hypoxia-inducible-factor-1 in trauma and critical care

Dorian A Bogdanovski et al. J Crit Care. 2017 Dec.

Abstract

HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery. In this review, the function of HIF-1 is examined, as well as its clinical significance with regard to trauma and critical care. Using this information, we then identify potential points of treatment and intervention.

Keywords: HIF-1; Hypoxia; Inflammation; Ischemia; Sepsis.

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