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. 2017 Aug;14(2):1463-1466.
doi: 10.3892/etm.2017.4643. Epub 2017 Jun 22.

Correlation study between gene and respiratory disease in children

Huaibin Liu  1 , Jie Min  1 , Haomiao Sun  1 , Chong-Lin Zhang  2
Affiliations

Correlation study between gene and respiratory disease in children

Huaibin Liu et al. Exp Ther Med. 2017 Aug.

Abstract

The study was designed to explore the correlation between c-Jun N-terminal kinase 1 (JNK1) gene and bronchitis in children with respiratory diseases. From April 2013 to April 2015, 32 cases of children who were admitted to our hospital for bronchitis were selected as the observation group, while 28 cases of normal children in the same period were selected as the control group. The JNK1 gene expression level in the blood of patients of the control and observation groups was detected by quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and western blot analysis. Additionally, the correlation between the levels of JNK1 expression and bronchitis in children was statistically analyzed using SPSS software. JNK1 expression significantly increased in the observation group compared to the control group, and a significant difference was identified (P<0.05). Furthermore, from the detection of JNK1 protein content of blood of child bronchitis with different conditions, we found JNK1 expression gradually increased with the aggravation of bronchitis in children, showing a positive correlation. JNK1 expression was significantly higher in the blood of patients with acute pediatric bronchitis than that of patients with chronic bronchitis. In conclusion, JNK1 promotes the production and deterioration of bronchitis in children, which provides a theoretical and experimental basis for the diagnosis and treatment of children afflicted with bronchitis.

Keywords: c-Jun N-terminal kinase 1; diagnosis and treatment of bronchial asthma in children with respiratory diseases.

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Figures

Figure 1.
Figure 1.
Level of mRNA expression of JNK1 in healthy children and children with bronchitis. JNK1, c-Jun N-terminal kinase 1.
Figure 2.
Figure 2.
Level of protein expression of JNK1 in the control and observation groups was detected by western blotting. (A) Normal children sample. (B) Pediatric bronchitis sample. JNK1, c-Jun N-terminal kinase 1.
Figure 3.
Figure 3.
Level of JNK1 protein expression in patients with different conditions of bronchitis. JNK1, c-Jun N-terminal kinase 1. #Compared with controlgroup, P<0.05; *compared with control group, P<0.01.
Figure 4.
Figure 4.
Level of JNK1 gene expression in bronchitis patients with different conditions. JNK1, c-Jun N-terminal kinase 1. *Compared with control group, P<0.01.
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References

    1. Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M. c-Jun NH2- terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 2008;68:5031–5039. doi: 10.1158/0008-5472.CAN-07-6332. - DOI - PubMed
    1. Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development. 2011;138:1925–1934. doi: 10.1242/dev.060020. - DOI - PMC - PubMed
    1. Lu A, Wang L, Zhang X, Zhang M. Combined treatment for child refractory Mycoplasma pneumoniae pneumonia with ciprofloxacin and glucocorticoid. Pediatr Pulmonol. 2011;46:1093–1097. doi: 10.1002/ppul.21481. - DOI - PubMed
    1. Adékambi T, Drancourt M. Isolation of Mycobacterium septicum from the sputum of a patient suffering from hemoptoic pneumonia. Res Microbiol. 2006;157:466–470. doi: 10.1016/j.resmic.2005.10.006. - DOI - PubMed
    1. Kang CD, Ahn BK, Jeong CS, Kim KW, Lee HJ, Yoo SD, Chung BS, Kim SH. Downregulation of JNK/SAPK activity is associated with the cross-resistance to P-glycoprotein-unrelated drugs in multidrug-resistant FM3A/M cells overexpressing P-glycoprotein. Exp Cell Res. 2000;256:300–307. doi: 10.1006/excr.2000.4807. - DOI - PubMed