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. 2017 Jun 15;5(8):1407-1408.
doi: 10.1002/ccr3.1036. eCollection 2017 Aug.

A fatal case of Rosai-Dorfman disease

Daniel Bulyashki  1 , Zarina Brady  2 , Shahswar Arif  2 , Nikolay Tsvetkov  1 , Radoslav Stoyanov Radev  1   3
Affiliations

A fatal case of Rosai-Dorfman disease

Daniel Bulyashki et al. Clin Case Rep. .

Abstract

As Rosai-Dorfman Disease presents generally nonspecific symptoms, differential diagnosis can be of great learning curve for physicians. Additionally, RDD does not usually threaten life and spontaneous remission is frequently observed. However, unusually in our case the patient passed away within 1 month of confirmed diagnosis.

Keywords: Emperipolesis; Lymphodenopathy; Rosai–Dorfman disease; fatal; nonspecific symptoms.

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Figures

Figure 1
Figure 1
Immunohistochemical analysis showing histiocytes staining strongly for CD68 protein, indicating the presence of lymphocytes within cytoplasmic vacuoles. (Magnification X40; CD68).
Figure 2
Figure 2
Expansion of sinusoids with an uncontrolled expression of plasma cells, lymphocytes, and histiocytes with large oval nuclei. (Magnification X400; Haematoxylin stain).
Figure 3
Figure 3
CT scan showing axillary lymph nodes.
See this image and copyright information in PMC

References

    1. Warpe, B. M. , and More S. V.. 2014. Rosai‐Dorfman disease: a rare clinico‐pathological presentation. Australas. Med. J. 7:68–72. - PMC - PubMed
    1. Dalia, S. , Sagatys E., Sokol L., and Kubal T.. 2014. Rosai‐Dorfman disease: tumor biology, clinical features, pathology, and treatment. Cancer Control 21:322–327. - PubMed

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