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Comment
. 2017 Aug;284(15):2375-2377.
doi: 10.1111/febs.14156.

Chaperoning the DNA damage response

Travis H Stracker  1
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Free article
Comment

Chaperoning the DNA damage response

Travis H Stracker. FEBS J. 2017 Aug.
Free article

Abstract

The NBN component of the MRE11-RAD50-NBN (MRN) complex and the ATM kinase have been identified as clients of the HSP90α chaperone. Inhibition of HSP90 leads to reduced stability of NBN and ATM and an impaired DNA damage response. These results identify new regulatory details of the DNA damage response and further explain the chemosensitizing effects of HSP90 inhibitors.

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