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. 1986 Dec 13;2(8520):1351-3.
doi: 10.1016/s0140-6736(86)92003-9.

Islet-cell antibodies and insulin autoantibodies in association with common viral infections

H J Bodansky, P J Grant, B M Dean, J McNally, G F Bottazzo, M H Hambling, J K Wales

Islet-cell antibodies and insulin autoantibodies in association with common viral infections

H J Bodansky et al. Lancet. .

Abstract

The appearance of islet-cell antibodies (ICA) and insulin autoantibodies (IAA) was sought in a prospective study of subjects with acute infections (mumps, rubella, chickenpox, and measles) followed for 6 months. IAA appeared in many patients' serum samples after these acute infections, IgM-IAA being more prevalent than IgG-IAA; there was a particularly high incidence (81%) after chickenpox. ICA were detected in 2 subjects--in 1 after rubella and in the other after measles, but this patient had evidence of previous rubella and a strong autoimmune family history. ICA did not appear after mumps. It is postulated that viral infections may trigger the production of IgM-IAA by a common mechanism involving polyclonal immunocyte activation.

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