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. 2018 Jul-Sep;14(3):185-191.
doi: 10.4103/jmas.JMAS_223_16.

Laparoscopic versus open treatment of gallbladder cancer: A systematic review and meta-analysis

Xin Zhao  1 , Xiang Yang Li  1 , Wu Ji  1
Affiliations

Laparoscopic versus open treatment of gallbladder cancer: A systematic review and meta-analysis

Xin Zhao et al. J Minim Access Surg. 2018 Jul-Sep.

Abstract

Background: The aim of this review was to evaluate the effect of laparoscopic surgery on the treatment of patients with gallbladder cancer (GBC).

Methods:: A comprehensive search of Medline and Cochrane Library was conducted to identify relevant articles. A meta-analysis was subsequently performed.

Results:: A total of 20 studies including 1217 patients met the inclusion criteria. The meta-analysis showed that the 5-year survival rate was significant higher in laparoscopic group than open group (48.4% vs. 38.5%; odds ratio [OR], 1.63; 95% confidence interval [CI], 1.22-2.19; P = 0.001). Although the scar recurrence rate was significant higher in laparoscopic group than open group (7.1% vs. 4.0%; OR, 2.10; 95% CI, 1.11-3.96; P = 0.02), the overall recurrence rates between two groups were not significant different (44.8% vs. 42.2%; OR, 0.86; 95% CI, 0.64-1.14; P = 0.29). In addition, compared with open extended cholecystectomy (EC), laparoscopic EC (LEC) was associated with less intraoperative blood loss, shorter post-operative hospital stays and insignificant less complication rate (10.0% vs. 18.3%; OR, 0.51; 95% CI, 0.15-1.73; P = 0.28).

Conclusion: Laparoscopic simple cholecystectomy does not lead to a worse prognosis when applied on patients with GBC. LEC can be performed in specialised expert centres on elective patients.

Keywords: Gallbladder cancer; laparoscopic; meta-analysis; open.

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Conflict of interest statement

There are no conflicts of interest

Figures

Figure 1
Figure 1
Flow diagram for study selection process
Figure 2
Figure 2
Meta-analysis of 5-year survival rate
Figure 3
Figure 3
Meta-analysis of recurrence rate
Figure 4
Figure 4
Meta-analysis of scar recurrence
Figure 5
Figure 5
Meta-analysis of complication rate
See this image and copyright information in PMC

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References

    1. Dorobisz T, Dorobisz K, Chabowski M, Pawlowski W, Janczak D, Patrzalek D, et al. Incidental gallbladder cancer after cholecystectomy: 1990 to 2014. Onco Targets Ther. 2016;9:4913–6. - PMC - PubMed
    1. Choi KS, Choi SB, Park P, Kim WB, Choi SY. Clinical characteristics of incidental or unsuspected gallbladder cancers diagnosed during or after cholecystectomy: A systematic review and meta-analysis. World J Gastroenterol. 2015;21:1315–23. - PMC - PubMed
    1. Zhang WJ, Xu GF, Zou XP, Wang WB, Yu JC, Wu GZ, et al. Incidental gallbladder carcinoma diagnosed during or after laparoscopic cholecystectomy. World J Surg. 2009;33:2651–6. - PubMed
    1. Cavallaro A, Piccolo G, Di Vita M, Zanghì A, Cardì F, Di Mattia P, et al. Managing the incidentally detected gallbladder cancer: Algorithms and controversies. Int J Surg. 2014;12(Suppl 2):S108–19. - PubMed
    1. Tian YH, Ji X, Liu B, Yang GY, Meng XF, Xia HT, et al. Surgical treatment of incidental gallbladder cancer discovered during or following laparoscopic cholecystectomy. World J Surg. 2015;39:746–52. - PubMed

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