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Comment
. 2017 Sep;14(9):733-735.
doi: 10.1038/cmi.2017.51. Epub 2017 Aug 7.

Peripheral clonal selection shapes the human γδ T-cell repertoire

Biagio Di Lorenzo  1   2 , Julie Déchanet-Merville  3 , Bruno Silva-Santos  1
Affiliations
Comment

Peripheral clonal selection shapes the human γδ T-cell repertoire

Biagio Di Lorenzo et al. Cell Mol Immunol. 2017 Sep.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Graphical representation of the dynamics of the human γδ T-cell repertoire. (a) Prenatal generation of γδ T cells is unfocused and unbiased. At birth, the human γδ repertoire in blood is variable, exhibiting Vγ2, Vγ3, Vγ4, Vγ5, Vδ1, Vδ3 and Vδ5 chain usage and no bias toward Vγ9 and Vδ2. (b) Up to 40% of the adult repertoire is composed of the 20 most abundant clones. The focus toward the Vγ9Vδ2 chain rearrangement (purple circles) is driven by postnatal proliferation in response to pathogen- or tumor-derived phosphoantigens. (c) AlloHSCT strongly perturbs the adult γδ repertoire. However, 60 days after alloHSCT, the repertoire is fully reconstituted and qualitatively comparable to the host repertoires before transplantation but displays very different clonotypes compared with the donor. (d) CMV reactivation occurs 25–60 days after alloHSCT. The γδ T-cell repertoire recovery observed in alloHSCT is perturbed by the proliferation of a few, mainly Vγ9–Vδ2, clones that comprise 20–75% of the repertoire.
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